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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: ORBIMED ADVISORS LLC -->
          <cik>0001055951</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001787297</issuerCik>
      <issuerName>Passage BIO, Inc.</issuerName>
      <secFileNumber>001-39231</secFileNumber>
      <issuerAddress>
        <com:street1>One Commerce Square</com:street1>
        <com:street2>2005 Market Street, 39th Floor</com:street2>
        <com:city>Philadelphia</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19103</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>267-866-0312</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OrbiMed Private Investments VII, LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Themis Trading LLC</name>
        <address>
          <com:street1>10 Town Square</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Chatham</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07928</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1076120</noOfUnitsSold>
      <aggregateMarketValue>378364.00</aggregateMarketValue>
      <noOfUnitsOutstanding>62148274</noOfUnitsOutstanding>
      <approxSaleDate>06/24/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>03/03/2020</acquiredDate>
      <natureOfAcquisitionTransaction>IPO</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1076120</amountOfSecuritiesAcquired>
      <paymentDate>03/03/2020</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>OrbiMed Private Investments VII, LP</name>
        <address>
          <com:street1>601 Lexington Ave., 54th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/15/2025</saleDate>
      <amountOfSecuritiesSold>10326</amountOfSecuritiesSold>
      <grossProceeds>3924.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>OrbiMed Private Investments VII, LP</name>
        <address>
          <com:street1>601 Lexington Ave., 54th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/16/2025</saleDate>
      <amountOfSecuritiesSold>61638</amountOfSecuritiesSold>
      <grossProceeds>20341.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>OrbiMed Private Investments VII, LP</name>
        <address>
          <com:street1>601 Lexington Ave., 54th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/17/2025</saleDate>
      <amountOfSecuritiesSold>77090</amountOfSecuritiesSold>
      <grossProceeds>25440.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>OrbiMed Private Investments VII, LP</name>
        <address>
          <com:street1>601 Lexington Ave., 54th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/22/2025</saleDate>
      <amountOfSecuritiesSold>78049</amountOfSecuritiesSold>
      <grossProceeds>26537.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>OrbiMed Private Investments VII, LP</name>
        <address>
          <com:street1>601 Lexington Ave., 54th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/23/2025</saleDate>
      <amountOfSecuritiesSold>89328</amountOfSecuritiesSold>
      <grossProceeds>30372.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>OrbiMed Private Investments VII, LP</name>
        <address>
          <com:street1>601 Lexington Ave., 54th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/24/2025</saleDate>
      <amountOfSecuritiesSold>68195</amountOfSecuritiesSold>
      <grossProceeds>21822.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>OrbiMed Capital GP VII LLC is the general partner of OrbiMed Private Investments VII, LP. OrbiMed Advisors LLC is the managing member of OrbiMed Capital GP VII LLC.</remarks>
    <noticeSignature>
      <noticeDate>06/24/2025</noticeDate>
      <signature>/s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Private Investments VII, LP</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
