X0304 4 2011-10-31 0 0001396814 Pacira Pharmaceuticals, Inc. PCRX 0001055951 ORBIMED ADVISORS LLC 767 THIRD AVENUE, 30TH FLOOR NEW YORK NY 10017 0 0 1 0 0001432241 OrbiMed Capital GP III LLC 767 THIRD AVENUE, 30TH FLOOR NEW YORK NY 10017 0 0 1 0 0001055949 ISALY SAMUEL D 767 THIRD AVENUE, 30TH FLOOR NEW YORK NY 10017 0 0 1 0 Common Stock 2011-10-31 4 S 0 96554 10.5257 D 2732387 I See footnotes Common Stock 2011-10-31 4 S 0 887 10.5257 D 2731500 I See footnotes The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.00 to $10.82, inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission, upon request, full information regarding the shares sold at each separate price within the ranges set forth in footnote (1) of this Form 4. Of the aggregate shares of Common Stock reported as beneficially owned following the reported transactions, 2,705,700 shares are held of record by OrbiMed Private Investments III, LP ("OPI") and 25,800 shares are held of record by OrbiMed Associates III, LP ("Associates"). The shares held by OPI may be deemed to be indirectly beneficially owned by OrbiMed Capital GP III LLC ("Capital"), OrbiMed Advisors LLC ("Advisors") and Samuel D. Isaly ("Isaly"), and the shares held by Associates may be deemed to be indirectly beneficially owned by Advisors and Isaly. These shares were sold by OPI. Capital is the sole general partner of OPI. Advisors, a registered advisor under the Investment Advisers Act of 1940, as amended, is the sole managing member of Capital. By virtue of such relationships, Capital and Advisors have discretionary investment management authority with respect to the assets of OPI. Such authority includes the power to vote and otherwise dispose of the securities held by OPI. Isaly, a natural person, also may be deemed to have investment and voting power over the securities held by OPI in his capacity as the managing member of, and holder of a controlling interest in, Advisors. As a result, each of Capital Advisors and Isaly may be deemed to have beneficial ownership of the securities held by OPI. These shares were sold by Associates. Advisors is the sole general partner of Associates. By virtue of such relationship, Advisors has discretionary investment management authority with respect to the assets of Associates. Such authority includes the power to vote and otherwise dispose of securities held by Associates. Isaly also may be deemed to have voting and investment power over the securities held by Associates in his capacity as the managing member of, and holder of a controlling interest in, Advisors. As a result, each of Advisors and Isaly may be deemed to have beneficial ownership of the securities held by Associates. This report on Form 4 is jointly filed by Capital, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the reporting persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose. /s/ Samuel D. Isaly 2011-11-02