X0202 4 2004-06-23 0 0001126140 GIVEN IMAGING LTD GIVN 0001055951 ORBIMED ADVISORS LLC 767 THIRD AVENUE NEW YORK NY 10017 1 0 1 0 0001157524 ORBIMED CAPITAL LLC 767 THIRD AVENUE NEW YORK NY 10017 1 0 1 0 0001055949 ISALY SAMUEL D 767 THIRD AVE NEW YORK NY 10010 1 0 1 0 Common Stock 2004-06-23 4 S 0 170000 30.08 D 3872260 I see footnotes below Common Stock 2004-09-21 4 J 0 235005 39.32 D 3637255 I see footnotes below This relates to the in-kind distribution to investors in Caducues Private Investments, LP ("Caduceus") and in OrbiMed Associates LLC ("Associates"), over which OrbiMed Capital LLC ("Capital") and OrbiMed Advisors LLC ("Advisors"), respectively, have investment management discretion. As of the close of business on September 21, 2004, Reporting Persons held 3,637,255 shares of common stock, on behalf of other persons who have the right to receive or the power to direct the receipt of dividends from, or proceeds from sale of, such securities. Of the 3,637,255 shares, Caduceus, Associates, UBS Juniper Crossover Fund, LLC ("Juniper"), Eaton Vance Worldwide Health Sciences Portfolio ("Eaton") and Finsbury Worldwide Pharmaceutical Trust Plc ("Finsbury")) directly holds 2,252,889, 82,314, 330,000, 486,283 and 485,769 shares, respectively. OrbiMed Advisors LLC ("Advisors"), pursuant to its authority under its investment advisory contracts with Associates, Juniper and Eaton, may be considered to hold indirectly 898,597 shares of common stock and OrbiMed Capital LLC ("Capital"), pursuant to its authority under its investment advisory contract with Caduceus and Finsbury, may be considered to hold indirectly 2,738,658 shares of common stock. Advisors and Capital are registered advisers under the Investment Advisers Act of 1940, as amended, that act as investment advisers to certain collective investment funds which hold Shares of the Issuer. Samuel D. Isaly, a natural person, owns controlling interest in Advisors and Capital. Advisors acts as investment adviser to Associates, Juniper and Eaton. Capital acts as investment adviser to Caduceus and Finsbury . Pursuant to these agreements and relationships, Advisors and Capital have discretionary investment management authority with respect to the assets of Caduceus, Associates, Juniper, Eaton and Finsbury. Such authority includes the power to vote and otherwise dispose of securities purchased by Caduceus, Associates, Juniper, Eaton and Finsbury. The Reporting Persons may be deemed to be a director of the issuer by virtue of their having nominated a representative, now Jonathan Silverstein, to serve on the issuer's board of directors. The Reporting Persons disclaim beneficial ownership of the these securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person are the beneficial owners of such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purposes. /s/ Samuel D. Isaly 2004-09-28