4 2003-05-14 0 0001107216 ORCHID BIOSCIENCES INC ORCH 0001055949 ISALY SAMUEL D 1 0 0 0 Common Stock 2003-05-14 4 S 0 1265 0.9196 D 7286 I By OrbiMed Advisors LLC (see footnote 1) Common Stock 2003-05-15 4 S 0 2493 0.8461 D 4793 I By OrbiMed Advisors LLC (see footnote 1) Common Stock 2003-05-16 4 S 0 1073 0.8345 D 3720 I By OrbiMed Advisors LLC (see footnote 1) Common Stock 2003-05-19 4 S 0 1533 0.7799 D 2187 I By OrbiMed Advisors LLC (see footnote 1) Common Stock 2003-05-20 4 S 0 2187 0.7755 D 0 I By OrbiMed Advisors LLC (see footnote 1) Non-Statutory Stock Options 1.25 2003-05-20 4 P 0 0 0 A 2002-12-31 2009-12-31 Common Stock 20000 20000 I By OrbiMed Advisors LLC (see footnote 2) OrbiMed Advisors LLC has investment management discretion over a number of collective investment funds. The shares reported here reflect the reporting person's indirect ownership as an investor in one or more of such funds. OrbiMed Advisors LLC was granted non-statutory stock options by the issuer. The reporting person is a controlling person of OrbiMed Advisors LLC. Samuel D. Isaly 2003-05-20