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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Wgq/Hmqxp9Cq+o1L5/7u6ZEcKvv7RA+HATniUXKhzwK5Lgk6/qEddKvqwgI0eUCZ
 mw99qLqTnbEtW8jNJIJ70A==

<SEC-DOCUMENT>0000921895-08-001888.txt : 20080625
<SEC-HEADER>0000921895-08-001888.hdr.sgml : 20080625
<ACCEPTANCE-DATETIME>20080625175120
ACCESSION NUMBER:		0000921895-08-001888
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080623
FILED AS OF DATE:		20080625
DATE AS OF CHANGE:		20080625

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PHARMACYCLICS INC
		CENTRAL INDEX KEY:			0000949699
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943148201
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		PHARMACYCLICS INC
		STREET 2:		995 E ARQUES AVE
		CITY:			SUNNYVALE
		STATE:			CA
		ZIP:			94085-4521
		BUSINESS PHONE:		408 774 0330

	MAIL ADDRESS:	
		STREET 1:		PHARMACYCLICS INC
		STREET 2:		995 E ARQUES AVE
		CITY:			SUNNYVALE
		STATE:			CA
		ZIP:			94085-4521

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DUGGAN ROBERT W
		CENTRAL INDEX KEY:			0001055919

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-26658
		FILM NUMBER:		08917485

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		8059623755

	MAIL ADDRESS:	
		STREET 1:		1933 CLIFF DRIVE #30
		CITY:			SANTA BARBARA
		STATE:			CA
		ZIP:			93107
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>dug7.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-06-23</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000949699</issuerCik>
        <issuerName>PHARMACYCLICS INC</issuerName>
        <issuerTradingSymbol>PCYC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001055919</rptOwnerCik>
            <rptOwnerName>DUGGAN ROBERT W</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1933 CLIFF DRIVE #30</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SANTA BARBARA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>93107</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2008-06-23</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>82018</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.7000</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4776857</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>415760</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Managed Accounts</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1909676</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By RWD Acquisition I LLC</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Shares held in managed accounts pursuant to agreements with Robert W. Duggan &amp; Associates (&quot;RWD&amp;A&quot;), of which Robert W. Duggan is a principal.  Mr. Duggan disclaims beneficial ownership of such Shares except to the extent of his pecuniary interest theren.</footnote>
        <footnote id="F2">Shares owned directly by RWD Acquisition I LLC (&quot;RWD Acquisition&quot;).  As the sole member of RWD Acquisition, Robert W. Duggan may be deemed to beneficially own the Shares owned by RWD Acquisition.  Mr. Duggan disclaims beneficial ownership of such Shares except to the extent of his pecuniary interest therein.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Duggan, Robert W</signatureName>
        <signatureDate>2008-06-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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