-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001179110-04-018113.txt : 20040915
<SEC-HEADER>0001179110-04-018113.hdr.sgml : 20040915
<ACCEPTANCE-DATETIME>20040915174606
ACCESSION NUMBER:		0001179110-04-018113
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040914
FILED AS OF DATE:		20040915
DATE AS OF CHANGE:		20040915

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENETRONICS BIOMEDICAL CORP
		CENTRAL INDEX KEY:			0001055726
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				330024450
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		11199 SORRENTO VALLEY RD
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		6195976006

	MAIL ADDRESS:	
		STREET 1:		11199 SORRENTO VALLEY ROAD
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-1334

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GENETRONICS BIOMEDICAL LTD
		DATE OF NAME CHANGE:	19980213

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			LARSON EUGENE A
		CENTRAL INDEX KEY:			0001270204

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14888
		FILM NUMBER:		041032457

	BUSINESS ADDRESS:	
		STREET 1:		C/O GENETRONICS
		STREET 2:		11199 SORRENTO VALLEY RD
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-1334
		BUSINESS PHONE:		8584103108

	MAIL ADDRESS:	
		STREET 1:		2457 WEST SHORE DR.
		CITY:			LUMMI ISLAND
		STATE:			WA
		ZIP:			98262
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-09-14</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001055726</issuerCik>
        <issuerName>GENETRONICS BIOMEDICAL CORP</issuerName>
        <issuerTradingSymbol>GEB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001270204</rptOwnerCik>
            <rptOwnerName>LARSON EUGENE A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2457 WEST SHORE DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUMMI ISLAND</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98262</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Genetronics Biomedical Series Convertible Preferred Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2004-09-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>17647.06</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Genetronics Biomedical Corp Common Stock Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>8.80</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2004-09-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1544</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>8.80</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2004-09-14</value>
            </exerciseDate>
            <expirationDate>
                <value>2009-05-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Genetronics Biomedical Corporation Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1544</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1544</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Private purchase of Issuer's Series C Cumulative Convertible Preferred Stock from an investor of the Issuer.</footnote>
        <footnote id="F2">Convertible into 4,411 shares of the Issuer's Common Stock at $6.80 per share.</footnote>
        <footnote id="F3">Gives effect to the 1-for-4 reverse stock split of the Issuer's common stock, which became effective on September 13, 2004.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Eugene A. Larson</signatureName>
        <signatureDate>2004-09-14</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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