X0303 4 2010-11-29 0000203596 WESBANCO INC WSBC 0001055721 KNOX D BRUCE C/O WESBANCO, INC. ONE BANK PLAZA WHEELING WV 26003 1 Common Stock 2010-11-29 4 S 0 1500 17.53 D 148780 D Common Stock 2010-11-29 4 S 0 150 17.5325 D 148630 D Common Stock 2010-11-29 4 S 0 100 17.60 D 148530 D Common Stock 2010-11-29 4 S 0 2550 17.70 D 145980 D Common Stock 2010-11-29 4 S 0 711 17.72 D 145269 D Common Stock 2010-11-29 4 S 0 89 17.73 D 145180 D Common Stock 2010-11-29 4 S 0 300 17.74 D 144880 D Common Stock 2010-11-29 4 S 0 2856 17.75 D 142024 D Common Stock 2010-11-29 4 S 0 100 17.76 D 141924 D Common Stock 2010-11-29 4 S 0 3750 17.77 D 138174 D Common Stock 2010-11-29 4 S 0 300 17.85 D 137874 D Common Stock 2010-11-29 4 S 0 94 17.87 D 137780 D Common Stock 2010-11-29 4 S 0 78 17.88 D 137702 D Common Stock 2010-11-29 4 S 0 400 17.91 D 137302 D Common Stock 2010-11-29 4 S 0 22 17.92 D 137280 D Common Stock 2010-11-29 4 S 0 2000 18.00 D 135280 D Common Stock 1982 I By IRA The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 29, 2010. /s/ Paul M. Limbert, Attorney-in-Fact 2010-11-30