X0201 42003-09-11 0000716054 CYPRESS BIOSCIENCE INC cypb 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1100CEO and SecretaryCommon Stock2003-09-115G050000D35485IBy TrustCommon Stock105693DCommon Stock76847IBy 401(k) PlanGift to an organization not affilitated with the Reporting Person.Between June 1, 2002 and June 30, 2003, the reporting person acquired 34,921 shares of Cypress Bioscience, Inc. Common Stock under the Cypress Bioscience, Inc. 401(k) plan.Sabrina Martucci Johnson Attorney-in-Fact2003-09-17