X0306 4 2019-05-24 0 0001419041 Tocagen Inc TOCA 0001054917 GRUBER HARRY E C/O TOCAGEN INC. 4242 CAMPUS POINT COURT, SUITE 500 SAN DIEGO CA 92121 1 1 0 0 President, Science&Innovation Common Stock 2019-05-24 4 P 0 5000 4.5565 A 9744 D Common Stock 417753 I By The Harry Edward Gruber and Joan Diane Cunningham Trust, dated 7/12/1988 Includes 1,130 shares of Common Stock that were acquired by the Reporting Person on June 8, 2018 pursuant to the Issuer's Employee Stock Purchase Plan and 1,114 shares of Common Stock that were acquired by the Reporting Person on December 10, 2018 pursuant to the Issuer's Employee Stock Purchase Plan. /s/ Mark Foletta, Attorney-in-Fact 2019-05-29