AGENUS INC COM NEW 00847G705 3120 750000 SH DFND 1,2,3,4,5 750000 0 0 AGENUS INC COM NEW 00847G705 2080 500000 SH Call DFND 1,2,3,4,5 500000 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 13601 335000 SH DFND 1,2,3,4,5 335000 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 8120 200000 SH Call DFND 1,2,3,4,5 200000 0 0 ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 29636 375000 SH DFND 1,2,3,4,5 375000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 37662 600000 SH DFND 1,2,3,4,5 600000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 9416 150000 SH Call DFND 1,2,3,4,5 150000 0 0 APPLE INC COM 037833100 43596 400000 SH Call DFND 1,2,3,4,5 400000 0 0 ARRAY BIOPHARMA INC COM 04269X105 10945 3710000 SH DFND 1,2,3,4,5 3710000 0 0 AVEXIS INC COM 05366U100 4767 175000 SH DFND 1,2,3,4,5 175000 0 0 BANK AMER CORP COM 060505104 13520 1000000 SH DFND 1,2,3,4,5 1000000 0 0 BANK AMER CORP COM 060505104 60840 4500000 SH Call DFND 1,2,3,4,5 4500000 0 0 BIOGEN INC COM 09062X103 104128 400000 SH Call DFND 1,2,3,4,5 400000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 32992 400000 SH DFND 1,2,3,4,5 400000 0 0 BIOTIME INC COM 09066L105 3679 1282050 SH DFND 1,2,3,4,5 1282050 0 0 BLUEBIRD BIO INC COM 09609G100 21250 500000 SH DFND 1,2,3,4,5 500000 0 0 BLUE BUFFALO PET PRODS INC COM 09531U102 2950580 114987547 SH DFND 1,2,3,4 114987547 0 0 CELGENE CORP COM 151020104 36032 360000 SH DFND 1,2,3,4,5 360000 0 0 CELGENE CORP COM 151020104 30027 300000 SH Call DFND 1,2,3,4,5 300000 0 0 CELLDEX THERAPEUTICS INC NEW COM 15117B103 2552 675000 SH DFND 1,2,3,4,5 675000 0 0 CELLECTIS S A SPONSORED ADS 15117K103 5775 210000 SH DFND 1,2,3,4,5 210000 0 0 CERES INC COM NEW 156773400 225 1024020 SH DFND 1,2,3,4 1024020 0 0 CHEMOCENTRYX INC COM 16383L106 2241 900000 SH DFND 1,2,3,4,5 900000 0 0 CITIGROUP INC COM NEW 172967424 10438 250000 SH DFND 1,2,3,4,5 250000 0 0 CITIGROUP INC COM NEW 172967424 20875 500000 SH Call DFND 1,2,3,4,5 500000 0 0 COLUCID PHARMACEUTICALS INC COM 19716T101 35 5575 SH DFND 1,2,3,4 5575 0 0 DELPHI AUTOMOTIVE PLC SHS G27823106 20631 275000 SH DFND 1,2,3,4,5 275000 0 0 DELTA AIR LINES INC DEL COM NEW 247361702 9736 200000 SH DFND 1,2,3,4,5 200000 0 0 DIMENSION THERAPEUTICS INC COM 25433V105 2153 275000 SH DFND 1,2,3,4,5 275000 0 0 GAMING & LEISURE PPTYS INC COM 36467J108 2100 70000 SH DFND 1,2,3,4,5 70000 0 0 GOLDMAN SACHS GROUP INC COM 38141G104 31396 200000 SH DFND 1,2,3,4,5 200000 0 0 GOLDMAN SACHS GROUP INC COM 38141G104 156980 1000000 SH Call DFND 1,2,3,4,5 1000000 0 0 IGNYTA INC COM 451731103 3385 500000 SH DFND 1,2,3,4,5 500000 0 0 INCYTE CORP COM 45337C102 43482 600000 SH DFND 1,2,3,4,5 600000 0 0 IONIS PHARMACEUTICALS INC COM 462222100 14175 350000 SH DFND 1,2,3,4,5 350000 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2373 216879 SH DFND 1,2,3,4 216879 0 0 JPMORGAN CHASE & CO COM 46625H100 11844 200000 SH DFND 1,2,3,4,5 200000 0 0 JPMORGAN CHASE & CO COM 46625H100 14805 250000 SH Call DFND 1,2,3,4,5 250000 0 0 JUNO THERAPEUTICS INC COM 48205A109 10094 265000 SH DFND 1,2,3,4,5 265000 0 0 JUNO THERAPEUTICS INC COM 48205A109 3809 100000 SH Call DFND 1,2,3,4,5 100000 0 0 KITE PHARMA INC COM 49803L109 22266 485000 SH DFND 1,2,3,4,5 485000 0 0 LENDINGCLUB CORP COM 52603A109 9338 1125000 SH DFND 1,2,3,4,5 1125000 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 9480 793327 SH DFND 1,2,3,4,5 793327 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 677860 56724650 SH DFND 1,2,3,4 56724650 0 0 MASTERCARD INC CL A 57636Q104 18900 200000 SH DFND 1,2,3,4,5 200000 0 0 METLIFE INC COM 59156R108 10326 235000 SH DFND 1,2,3,4,5 235000 0 0 METLIFE INC COM 59156R108 32955 750000 SH Call DFND 1,2,3,4,5 750000 0 0 MORGAN STANLEY COM NEW 617446448 12505 500000 SH DFND 1,2,3,4,5 500000 0 0 NANTKWEST INC COM 63016Q102 1850 225000 SH DFND 1,2,3,4,5 225000 0 0 NEKTAR THERAPEUTICS COM 640268108 27500 2000000 SH DFND 1,2,3,4,5 2000000 0 0 ONCOCYTE CORPORATION COM 68235C107 296 64102 SH DFND 1,2,3,4,5 64102 0 0 PALO ALTO NETWORKS INC COM 697435105 3263 20000 SH DFND 1,2,3,4,5 20000 0 0 PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 1065 500000 SH DFND 1,2,3,4,5 500000 0 0 REGENERON PHARMACEUTICALS COM 75886F107 10813 30000 SH Call DFND 1,2,3,4,5 30000 0 0 REGENXBIO INC COM 75901B107 1728 160000 SH DFND 1,2,3,4,5 160000 0 0 SAREPTA THERAPEUTICS INC COM 803607100 3904 200000 SH Call DFND 1,2,3,4,5 200000 0 0 SERES THERAPEUTICS INC COM 81750R102 5976 225000 SH DFND 1,2,3,4,5 225000 0 0 SPECTRANETICS CORP COM 84760C107 5082 350000 SH DFND 1,2,3,4,5 350000 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 24080 450000 SH Call DFND 1,2,3,4,5 450000 0 0 WAL-MART STORES INC COM 931142103 34245 500000 SH Call DFND 1,2,3,4,5 500000 0 0 WEIGHT WATCHERS INTL INC NEW COM 948626106 427811 29443300 SH DFND 1,2,3,4 29443300 0 0