The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AERCAP HOLDINGS NV | SHS | N00985106 | 17,171 | 375,000 | SH | DFND | 1,2,3,4,5 | 375,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 4,575 | 530,090 | SH | DFND | 1,2,3,4,5 | 530,090 | 0 | 0 | |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 17,782 | 160,000 | SH | DFND | 1,2,3,4,5 | 160,000 | 0 | 0 | |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 41,135 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 8,227 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 54,541 | 455,000 | SH | DFND | 1,2,3,4,5 | 455,000 | 0 | 0 | |
| AMAZON COM INC | COM | 023135106 | 28,216 | 65,000 | SH | DFND | 1,2,3,4,5 | 65,000 | 0 | 0 | |
| AMERICAN AIRLS GROUP INC | COM | 02376R102 | 15,974 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| AMERICAN AIRLS GROUP INC | COM | 02376R102 | 9,984 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| AMERICAN EXPRESS CO | COM | 025816109 | 34,974 | 450,000 | SH | Call | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 26,749 | 3,710,000 | SH | DFND | 1,2,3,4,5 | 3,710,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 2,163 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| BANK AMER CORP | COM | 060505104 | 17,020 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| BANK AMER CORP | COM | 060505104 | 42,550 | 2,500,000 | SH | Call | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 | 141,379 | 350,000 | SH | Call | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 59,499 | 435,000 | SH | DFND | 1,2,3,4,5 | 435,000 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 27,356 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| BIOTIME INC | COM | 09066L105 | 4,654 | 1,282,050 | SH | DFND | 1,2,3,4,5 | 1,282,050 | 0 | 0 | |
| BIOTIME INC | COM | 09066L105 | 2,178 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 | 33,674 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| CASTLIGHT HEALTH INC | CL B | 14862Q100 | 2,035 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| CELGENE CORP | COM | 151020104 | 69,441 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM | 15117B103 | 6,305 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| CELLECTIS S A | SPONSORED ADS | 15117K103 | 4,510 | 125,000 | SH | DFND | 1,2,3,4,5 | 125,000 | 0 | 0 | |
| CERES INC | COM NEW | 156773400 | 1,997 | 1,024,020 | SH | DFND | 1,2,3,4 | 1,024,020 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 7,407 | 900,000 | SH | DFND | 1,2,3,4,5 | 900,000 | 0 | 0 | |
| CITIGROUP INC | COM NEW | 172967424 | 22,096 | 400,000 | SH | Call | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |
| COLUCID PHARMACEUTICALS INC | COM | 19716T101 | 50 | 5,575 | SH | DFND | 1,2,3,4 | 5,575 | 0 | 0 | |
| CROWN CASTLE INTL CORP NEW | COM | 22822V101 | 16,060 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| DELTA AIR LINES INC DEL | COM NEW | 247361702 | 8,216 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| GENERAL ELECTRIC CO | COM | 369604103 | 53,140 | 2,000,000 | SH | Call | DFND | 1,2,3,4,5 | 2,000,000 | 0 | 0 |
| GENERAL MTRS CO | COM | 37045V100 | 14,999 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
| GENERAL MTRS CO | COM | 37045V100 | 33,330 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 11,708 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | COM | 38141G104 | 62,637 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| GOOGLE INC | CL C | 38259P706 | 117,115 | 225,000 | SH | Call | DFND | 1,2,3,4,5 | 225,000 | 0 | 0 |
| HILTON WORLDWIDE HLDGS INC | COM | 43300A104 | 15,153 | 550,000 | SH | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 6,791 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 50,021 | 480,000 | SH | DFND | 1,2,3,4,5 | 480,000 | 0 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 2,616 | 216,879 | SH | DFND | 1,2,3,4 | 216,879 | 0 | 0 | |
| ISIS PHARMACEUTICALS INC | COM | 464330109 | 23,020 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| JD COM INC | SPON ADR CL A | 47215P106 | 3,410 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| JPMORGAN CHASE & CO | COM | 46625H100 | 40,656 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| JUMEI INTL HLDG LTD | SPONSORED ADR | 48138L107 | 11,420 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| JUNO THERAPEUTICS INC | COM | 48205A109 | 10,133 | 190,000 | SH | DFND | 1,2,3,4,5 | 190,000 | 0 | 0 | |
| KITE PHARMA INC | COM | 49803L109 | 25,912 | 425,000 | SH | DFND | 1,2,3,4,5 | 425,000 | 0 | 0 | |
| LENDINGCLUB CORP | COM | 52603A109 | 15,856 | 1,075,000 | SH | DFND | 1,2,3,4,5 | 1,075,000 | 0 | 0 | |
| LENDINGCLUB CORP | COM | 52603A109 | 3,688 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 6,386 | 793,327 | SH | DFND | 1,2,3,4,5 | 793,327 | 0 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 456,633 | 56,724,651 | SH | DFND | 1,2,3,4 | 56,724,651 | 0 | 0 | |
| LINKEDIN CORP | COM CL A | 53578A108 | 27,172 | 131,500 | SH | DFND | 1,2,3,4,5 | 131,500 | 0 | 0 | |
| MASTERCARD INC | CL A | 57636Q104 | 37,392 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| MCDONALDS CORP | COM | 580135101 | 19,014 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| MERCK & CO INC NEW | COM | 58933Y105 | 28,465 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| METLIFE INC | COM | 59156R108 | 33,594 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| MICRON TECHNOLOGY INC | COM | 595112103 | 18,840 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 1,928 | 61,276 | SH | DFND | 1,2,3,4,5 | 61,276 | 0 | 0 | |
| MOBILEYE N V AMSTELVEEN | ORD SHS | N51488117 | 26,585 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| MORGAN STANLEY | COM NEW | 617446448 | 29,093 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 | 21,267 | 1,700,000 | SH | DFND | 1,2,3,4,5 | 1,700,000 | 0 | 0 | |
| PARNELL PHARMACEUT HLDGS LTD | SHS | Q73622104 | 2,475 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| QUALCOMM INC | COM | 747525103 | 31,315 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| REALOGY HLDGS CORP | COM | 75605Y106 | 4,672 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| SERES THERAPEUTICS INC | COM | 81750R102 | 6,642 | 160,057 | SH | DFND | 1,2,3,4,5 | 160,057 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 26,595 | 450,000 | SH | Call | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 |
| WAL-MART STORES INC | COM | 931142103 | 118,098 | 1,665,000 | SH | Call | DFND | 1,2,3,4,5 | 1,665,000 | 0 | 0 |
| WEIGHT WATCHERS INTL INC NEW | COM | 948626106 | 142,800 | 29,443,300 | SH | DFND | 1,2,3,4 | 29,443,300 | 0 | 0 | |
| XOMA CORP DEL | COM | 98419J107 | 4,656 | 1,200,000 | SH | DFND | 1,2,3,4,5 | 1,200,000 | 0 | 0 | |
| XOMA CORP DEL | COM | 98419J107 | 1,552 | 400,000 | SH | Call | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |
| YUM BRANDS INC | COM | 988498101 | 45,040 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| YY INC | ADS REPCOM CLA | 98426T106 | 3,476 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |