AERCAP HOLDINGS NV SHS N00985106 17171 375000 SH DFND 1,2,3,4,5 375000 0 0 AGENUS INC COM NEW 00847G705 4575 530090 SH DFND 1,2,3,4,5 530090 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 17782 160000 SH DFND 1,2,3,4,5 160000 0 0 ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 41135 500000 SH DFND 1,2,3,4,5 500000 0 0 ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 8227 100000 SH Call DFND 1,2,3,4,5 100000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 54541 455000 SH DFND 1,2,3,4,5 455000 0 0 AMAZON COM INC COM 023135106 28216 65000 SH DFND 1,2,3,4,5 65000 0 0 AMERICAN AIRLS GROUP INC COM 02376R102 15974 400000 SH DFND 1,2,3,4,5 400000 0 0 AMERICAN AIRLS GROUP INC COM 02376R102 9984 250000 SH Call DFND 1,2,3,4,5 250000 0 0 AMERICAN EXPRESS CO COM 025816109 34974 450000 SH Call DFND 1,2,3,4,5 450000 0 0 ARRAY BIOPHARMA INC COM 04269X105 26749 3710000 SH DFND 1,2,3,4,5 3710000 0 0 ARRAY BIOPHARMA INC COM 04269X105 2163 300000 SH Call DFND 1,2,3,4,5 300000 0 0 BANK AMER CORP COM 060505104 17020 1000000 SH DFND 1,2,3,4,5 1000000 0 0 BANK AMER CORP COM 060505104 42550 2500000 SH Call DFND 1,2,3,4,5 2500000 0 0 BIOGEN INC COM 09062X103 141379 350000 SH Call DFND 1,2,3,4,5 350000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 59499 435000 SH DFND 1,2,3,4,5 435000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 27356 200000 SH Call DFND 1,2,3,4,5 200000 0 0 BIOTIME INC COM 09066L105 4654 1282050 SH DFND 1,2,3,4,5 1282050 0 0 BIOTIME INC COM 09066L105 2178 600000 SH Call DFND 1,2,3,4,5 600000 0 0 BLUEBIRD BIO INC COM 09609G100 33674 200000 SH DFND 1,2,3,4,5 200000 0 0 CASTLIGHT HEALTH INC CL B 14862Q100 2035 250000 SH DFND 1,2,3,4,5 250000 0 0 CELGENE CORP COM 151020104 69441 600000 SH Call DFND 1,2,3,4,5 600000 0 0 CELLDEX THERAPEUTICS INC NEW COM 15117B103 6305 250000 SH DFND 1,2,3,4,5 250000 0 0 CELLECTIS S A SPONSORED ADS 15117K103 4510 125000 SH DFND 1,2,3,4,5 125000 0 0 CERES INC COM NEW 156773400 1997 1024020 SH DFND 1,2,3,4 1024020 0 0 CHEMOCENTRYX INC COM 16383L106 7407 900000 SH DFND 1,2,3,4,5 900000 0 0 CITIGROUP INC COM NEW 172967424 22096 400000 SH Call DFND 1,2,3,4,5 400000 0 0 COLUCID PHARMACEUTICALS INC COM 19716T101 50 5575 SH DFND 1,2,3,4 5575 0 0 CROWN CASTLE INTL CORP NEW COM 22822V101 16060 200000 SH Call DFND 1,2,3,4,5 200000 0 0 DELTA AIR LINES INC DEL COM NEW 247361702 8216 200000 SH DFND 1,2,3,4,5 200000 0 0 GENERAL ELECTRIC CO COM 369604103 53140 2000000 SH Call DFND 1,2,3,4,5 2000000 0 0 GENERAL MTRS CO COM 37045V100 14999 450000 SH DFND 1,2,3,4,5 450000 0 0 GENERAL MTRS CO COM 37045V100 33330 1000000 SH Call DFND 1,2,3,4,5 1000000 0 0 GILEAD SCIENCES INC COM 375558103 11708 100000 SH Call DFND 1,2,3,4,5 100000 0 0 GOLDMAN SACHS GROUP INC COM 38141G104 62637 300000 SH Call DFND 1,2,3,4,5 300000 0 0 GOOGLE INC CL C 38259P706 117115 225000 SH Call DFND 1,2,3,4,5 225000 0 0 HILTON WORLDWIDE HLDGS INC COM 43300A104 15153 550000 SH DFND 1,2,3,4,5 550000 0 0 IGNYTA INC COM 451731103 6791 450000 SH DFND 1,2,3,4,5 450000 0 0 INCYTE CORP COM 45337C102 50021 480000 SH DFND 1,2,3,4,5 480000 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2616 216879 SH DFND 1,2,3,4 216879 0 0 ISIS PHARMACEUTICALS INC COM 464330109 23020 400000 SH DFND 1,2,3,4,5 400000 0 0 JD COM INC SPON ADR CL A 47215P106 3410 100000 SH DFND 1,2,3,4,5 100000 0 0 JPMORGAN CHASE & CO COM 46625H100 40656 600000 SH Call DFND 1,2,3,4,5 600000 0 0 JUMEI INTL HLDG LTD SPONSORED ADR 48138L107 11420 500000 SH DFND 1,2,3,4,5 500000 0 0 JUNO THERAPEUTICS INC COM 48205A109 10133 190000 SH DFND 1,2,3,4,5 190000 0 0 KITE PHARMA INC COM 49803L109 25912 425000 SH DFND 1,2,3,4,5 425000 0 0 LENDINGCLUB CORP COM 52603A109 15856 1075000 SH DFND 1,2,3,4,5 1075000 0 0 LENDINGCLUB CORP COM 52603A109 3688 250000 SH Call DFND 1,2,3,4,5 250000 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 6386 793327 SH DFND 1,2,3,4,5 793327 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 456633 56724651 SH DFND 1,2,3,4 56724651 0 0 LINKEDIN CORP COM CL A 53578A108 27172 131500 SH DFND 1,2,3,4,5 131500 0 0 MASTERCARD INC CL A 57636Q104 37392 400000 SH DFND 1,2,3,4,5 400000 0 0 MCDONALDS CORP COM 580135101 19014 200000 SH Call DFND 1,2,3,4,5 200000 0 0 MERCK & CO INC NEW COM 58933Y105 28465 500000 SH Call DFND 1,2,3,4,5 500000 0 0 METLIFE INC COM 59156R108 33594 600000 SH Call DFND 1,2,3,4,5 600000 0 0 MICRON TECHNOLOGY INC COM 595112103 18840 1000000 SH Call DFND 1,2,3,4,5 1000000 0 0 MIRATI THERAPEUTICS INC COM 60468T105 1928 61276 SH DFND 1,2,3,4,5 61276 0 0 MOBILEYE N V AMSTELVEEN ORD SHS N51488117 26585 500000 SH DFND 1,2,3,4,5 500000 0 0 MORGAN STANLEY COM NEW 617446448 29093 750000 SH Call DFND 1,2,3,4,5 750000 0 0 NEKTAR THERAPEUTICS COM 640268108 21267 1700000 SH DFND 1,2,3,4,5 1700000 0 0 PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 2475 500000 SH DFND 1,2,3,4,5 500000 0 0 QUALCOMM INC COM 747525103 31315 500000 SH Call DFND 1,2,3,4,5 500000 0 0 REALOGY HLDGS CORP COM 75605Y106 4672 100000 SH DFND 1,2,3,4,5 100000 0 0 SERES THERAPEUTICS INC COM 81750R102 6642 160057 SH DFND 1,2,3,4,5 160057 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 26595 450000 SH Call DFND 1,2,3,4,5 450000 0 0 WAL-MART STORES INC COM 931142103 118098 1665000 SH Call DFND 1,2,3,4,5 1665000 0 0 WEIGHT WATCHERS INTL INC NEW COM 948626106 142800 29443300 SH DFND 1,2,3,4 29443300 0 0 XOMA CORP DEL COM 98419J107 4656 1200000 SH DFND 1,2,3,4,5 1200000 0 0 XOMA CORP DEL COM 98419J107 1552 400000 SH Call DFND 1,2,3,4,5 400000 0 0 YUM BRANDS INC COM 988498101 45040 500000 SH Call DFND 1,2,3,4,5 500000 0 0 YY INC ADS REPCOM CLA 98426T106 3476 50000 SH DFND 1,2,3,4,5 50000 0 0