The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACORDA THERAPEUTICS INC COM 00484M106 8,320 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
ACORDA THERAPEUTICS INC COM 00484M106 4,992 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
AGENUS INC COM NEW 00847G705 2,104 410,130 SH   DFND 1,2,3,4,5 410,130 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 13,202 140,000 SH   DFND 1,2,3,4,5 140,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 47,863 575,000 SH   DFND 1,2,3,4,5 575,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 8,324 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 49,077 470,000 SH   DFND 1,2,3,4,5 470,000 0 0
AMAZON COM INC COM 023135106 18,605 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
AMAZON COM INC COM 023135106 18,605 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 19,177 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 27,343 3,710,000 SH   DFND 1,2,3,4,5 3,710,000 0 0
AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 4,052 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
BANK AMER CORP COM 060505104 18,468 1,200,000 SH   DFND 1,2,3,4,5 1,200,000 0 0
BANK AMER CORP COM 060505104 76,950 5,000,000 SH Call DFND 1,2,3,4,5 5,000,000 0 0
BIOGEN INC COM 09062X103 99,226 235,000 SH Call DFND 1,2,3,4,5 235,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 59,818 480,000 SH   DFND 1,2,3,4,5 480,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 24,924 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
BIOTIME INC COM 09066L105 6,372 1,282,050 SH   DFND 1,2,3,4,5 1,282,050 0 0
BIOTIME INC COM 09066L105 1,988 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
BLUEBIRD BIO INC COM 09609G100 42,270 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
BRF SA SPONSORED ADR 10552T107 4,945 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
BRF SA SPONSORED ADR 10552T107 19,780 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
CASTLIGHT HEALTH INC CL B 14862Q100 1,940 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
CELGENE CORP COM 151020104 34,584 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 3,458 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CERES INC COM 156773103 2,703 8,192,167 SH   DFND 1,2,3,4 8,192,167 0 0
CHEMOCENTRYX INC COM 16383L106 6,040 800,000 SH   DFND 1,2,3,4,5 800,000 0 0
CITIZENS FINL GROUP INC COM 174610105 18,098 750,000 SH   DFND 1,2,3,4,5 750,000 0 0
DELPHI AUTOMOTIVE PLC SHS G27823106 15,948 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
DELPHI AUTOMOTIVE PLC SHS G27823106 7,974 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
GENERAL ELECTRIC CO COM 369604103 24,810 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
GENERAL MTRS CO COM 37045V100 15,000 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 18,797 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
GOOGLE INC CL C 38259P706 49,320 90,000 SH   DFND 1,2,3,4,5 90,000 0 0
HARLEY DAVIDSON INC COM 412822108 6,074 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
HARLEY DAVIDSON INC COM 412822108 6,074 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A104 8,886 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
IGNYTA INC COM 451731103 4,229 425,000 SH   DFND 1,2,3,4,5 425,000 0 0
IMMUNOGEN INC COM 45253H101 5,370 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
INCYTE CORP COM 45337C102 46,747 510,000 SH   DFND 1,2,3,4,5 510,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 3,470 216,879 SH   DFND 1,2,3,4 216,879 0 0
ISHARES US HOME CONS ETF 464288752 2,823 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
ISIS PHARMACEUTICALS INC COM 464330109 25,468 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
JPMORGAN CHASE & CO COM 46625H100 54,522 900,000 SH Call DFND 1,2,3,4,5 900,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 7,886 130,000 SH   DFND 1,2,3,4,5 130,000 0 0
KITE PHARMA INC COM 49803L109 21,630 375,000 SH   DFND 1,2,3,4,5 375,000 0 0
LENDINGCLUB CORP COM 52603A109 9,825 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 5,244 5,553,292 SH   DFND 1,2,3,4,5 5,553,292 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 373,248 397,072,574 SH   DFND 1,2,3,4 397,072,574 0 0
LINKEDIN CORP COM CL A 53578A108 27,485 110,000 SH   DFND 1,2,3,4,5 110,000 0 0
MASTERCARD INC CL A 57636Q104 30,237 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
MCDONALDS CORP COM 580135101 38,976 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
MERCK & CO INC NEW COM 58933Y105 97,716 1,700,000 SH Call DFND 1,2,3,4,5 1,700,000 0 0
METLIFE INC COM 59156R108 20,220 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
METLIFE INC COM 59156R108 55,605 1,100,000 SH Call DFND 1,2,3,4,5 1,100,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 7,330 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
MOBILEYE N V AMSTELVEEN ORD SHS N51488117 14,711 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
MORGAN STANLEY COM NEW 617446448 12,492 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
NEKTAR THERAPEUTICS COM 640268108 18,700 1,700,000 SH   DFND 1,2,3,4,5 1,700,000 0 0
NEKTAR THERAPEUTICS COM 640268108 3,300 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 2,455 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
REALOGY HLDGS CORP COM 75605Y106 10,233 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
SPARK THERAPEUTICS INC COM 84652J103 4,650 60,000 SH   DFND 1,2,3,4,5 60,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 103,215 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
TESLA MTRS INC COM 88160R101 7,551 40,000 SH   DFND 1,2,3,4,5 40,000 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 37,380 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
UNITED CONTL HLDGS INC COM 910047109 10,088 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
WAL-MART STORES INC COM 931142103 24,675 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 205,809 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0
XOMA CORP DEL COM 98419J107 4,368 1,200,000 SH   DFND 1,2,3,4,5 1,200,000 0 0
YELP INC CL A 985817105 14,205 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
YUM BRANDS INC COM 988498101 55,104 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0