The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 13,269 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 1,300 | 410,130 | SH | DFND | 1,2,3,4,5 | 410,130 | 0 | 0 | |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 3,915 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 13,764 | 205,000 | SH | DFND | 1,2,3,4,5 | 205,000 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 905 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| AMAZON COM INC | COM | 023135106 | 50,455 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| AMBIT BIOSCIENCES CORP | COM | 02318X100 | 2,280 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| AMERICAN INTL GROUP INC | COM NEW | 026874784 | 42,509 | 850,000 | SH | Call | DFND | 1,2,3,4,5 | 850,000 | 0 | 0 |
| AMGEN INC | COM | 031162100 | 18,501 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
| AMGEN INC | COM | 031162100 | 12,334 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 14,100 | 3,000,000 | SH | DFND | 1,2,3,4,5 | 3,000,000 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 37,373 | 1,375,000 | SH | DFND | 1,2,3,4,5 | 1,375,000 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 24,462 | 900,000 | SH | Call | DFND | 1,2,3,4,5 | 900,000 | 0 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A NEW | 05348P401 | 3,303 | 900,000 | SH | DFND | 1,2,3,4,5 | 900,000 | 0 | 0 | |
| AVANIR PHARMACEUTICALS INC | CL A NEW | 05348P401 | 4,771 | 1,300,000 | SH | Call | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 |
| BANK OF AMERICA CORPORATION | COM | 060505104 | 17,200 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| BIOGEN IDEC INC | COM | 09062X103 | 22,940 | 75,000 | SH | Call | DFND | 1,2,3,4,5 | 75,000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 35,810 | 525,000 | SH | DFND | 1,2,3,4,5 | 525,000 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 13,642 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 | 3,411 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
| BRF SA | SPONSORED ADR | 10552T107 | 8,929 | 446,900 | SH | DFND | 1,2,3,4,5 | 446,900 | 0 | 0 | |
| BRF SA | SPONSORED ADR | 10552T107 | 29,970 | 1,500,000 | SH | Call | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 25,975 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| CASTLIGHT HEALTH INC | CL B | 14862Q100 | 2,122 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| CEMENTOS PACASMAYO S A A | SPON ADR REP 5 | 15126Q109 | 2,251 | 256,975 | SH | DFND | 1,2,3,4,5 | 256,975 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 1,823 | 275,000 | SH | DFND | 1,2,3,4,5 | 275,000 | 0 | 0 | |
| CIT GROUP INC | COM NEW | 125581801 | 36,765 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
| CITIGROUP INC | COM NEW | 172967424 | 14,280 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| CITIGROUP INC | COM NEW | 172967424 | 88,060 | 1,850,000 | SH | Call | DFND | 1,2,3,4,5 | 1,850,000 | 0 | 0 |
| CERES INC | COM | 156773103 | 7,209 | 8,192,167 | SH | DFND | 1,2,3,4 | 8,192,167 | 0 | 0 | |
| COLGATE PALMOLIVE CO | COM | 194162103 | 16,218 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| COMCAST CORP NEW | CL A SPL | 20030N200 | 3,658 | 75,000 | SH | DFND | 1,2,3,4,5 | 75,000 | 0 | 0 | |
| DELPHI AUTOMOTIVE PLC | SHS | G27823106 | 10,179 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
| DELPHI AUTOMOTIVE PLC | SHS | G27823106 | 16,965 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| DOLLAR GEN CORP NEW | COM | 256677105 | 13,870 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| FREEPORT-MCMORAN COPPER & GO | COM | 35671D857 | 6,614 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| FURIEX PHARMACEUTICALS INC | COM | 36106P101 | 69,504 | 798,900 | SH | DFND | 1,2,3,4,5 | 798,900 | 0 | 0 | |
| FURIEX PHARMACEUTICALS INC | COM | 36106P101 | 8,700 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| GENERAL ELECTRIC CO | COM | 369604103 | 38,835 | 1,500,000 | SH | Call | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 |
| GENERAL MTRS CO | COM | 37045V100 | 12,047 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
| GENERAL MTRS CO | COM | 37045V100 | 43,025 | 1,250,000 | SH | Call | DFND | 1,2,3,4,5 | 1,250,000 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 17,715 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | COM | 38141G104 | 20,481 | 125,000 | SH | Call | DFND | 1,2,3,4,5 | 125,000 | 0 | 0 |
| GOOGLE INC | CL A | 38259P508 | 50,153 | 45,000 | SH | Call | DFND | 1,2,3,4,5 | 45,000 | 0 | 0 |
| HALLIBURTON CO | COM | 406216101 | 8,834 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| HARTFORD FINL SVCS GROUP INC | COM | 416515104 | 17,635 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| IGNYTA INC | COM | 451731103 | 2,490 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| IMMUNOGEN INC | COM | 45253H101 | 19,409 | 1,300,000 | SH | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 | |
| IMMUNOGEN INC | COM | 45253H101 | 5,226 | 350,000 | SH | Call | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 | 5,352 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| INTEL CORP | COM | 458140100 | 19,361 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 2,672 | 216,879 | SH | DFND | 1,2,3,4 | 216,879 | 0 | 0 | |
| ISHARES | CHINA LG-CAP ETF | 464287184 | 7,156 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| ISHARES | MSCI MEX CAP ETF | 464286822 | 9,593 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| ISHARES | NASDQ BIOTEC ETF | 464287556 | 70,920 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| ISHARES | US HOME CONS ETF | 464288752 | 18,165 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330109 | 4,321 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| JPMORGAN CHASE & CO | COM | 46625H100 | 15,178 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM | 528872104 | 9,607 | 5,553,292 | SH | DFND | 1,2,3,4,5 | 5,553,292 | 0 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM | 528872104 | 428,727 | 247,818,843 | SH | DFND | 1,2,3,4 | 247,818,843 | 0 | 0 | |
| LILLY ELI & CO | COM | 532457108 | 11,772 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| MACYS INC | COM | 55616P104 | 5,929 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| MARKET VECTORS ETF TR | OIL SVCS ETF | 57060U191 | 12,583 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| MEAD JOHNSON NUTRITION CO | COM | 582839106 | 12,471 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
| MEAD JOHNSON NUTRITION CO | COM | 582839106 | 8,314 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| MERCK & CO INC NEW | COM | 58933Y105 | 73,801 | 1,300,000 | SH | Call | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 |
| MERITOR INC | COM | 59001K100 | 3,675 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| METLIFE INC | COM | 59156R108 | 26,400 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| MGIC INVT CORP WIS | COM | 552848103 | 5,112 | 600,000 | SH | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
| MICRON TECHNOLOGY INC | COM | 595112103 | 9,464 | 400,000 | SH | Call | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 4,768 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| MORGAN STANLEY | COM NEW | 617446448 | 4,676 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 | 15,756 | 1,300,000 | SH | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 3,636 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| NEOGEN CORP | COM | 640491106 | 2,248 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |
| NOVAGOLD RES INC | COM NEW | 66987E206 | 4,332 | 1,200,000 | SH | Call | DFND | 1,2,3,4,5 | 1,200,000 | 0 | 0 |
| NVIDIA CORP | COM | 67066G104 | 17,910 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| OCWEN FINL CORP | COM NEW | 675746309 | 21,549 | 550,000 | SH | Call | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 |
| PEPSICO INC | COM | 713448108 | 50,100 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| PHARMACYCLICS INC | COM | 716933106 | 21,046 | 210,000 | SH | DFND | 1,2,3,4,5 | 210,000 | 0 | 0 | |
| PHARMACYCLICS INC | COM | 716933106 | 9,020 | 90,000 | SH | Call | DFND | 1,2,3,4,5 | 90,000 | 0 | 0 |
| QUALCOMM INC | COM | 747525103 | 43,373 | 550,000 | SH | Call | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 |
| RALPH LAUREN CORP | CL A | 751212101 | 8,047 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |
| RALPH LAUREN CORP | CL A | 751212101 | 8,047 | 50,000 | SH | Call | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 |
| REALOGY HLDGS CORP | COM | 75605Y106 | 6,518 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
| SOPHIRIS BIO INC | COM NEW | 83578Q209 | 3,330 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 130,907 | 700,000 | SH | Call | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 |
| STEMLINE THERAPEUTICS INC | COM | 85858C107 | 3,156 | 155,000 | SH | DFND | 1,2,3,4,5 | 155,000 | 0 | 0 | |
| TEREX CORP NEW | COM | 880779103 | 2,215 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 31,704 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| WEIGHT WATCHERS INTL INC NEW | COM | 948626106 | 590,506 | 28,749,089 | SH | DFND | 1,2,3,4 | 28,749,089 | 0 | 0 | |
| WELLS FARGO & CO NEW | COM | 949746101 | 24,870 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| XOMA CORP DEL | COM | 98419J107 | 5,210 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| YUM BRANDS INC | COM | 988498101 | 45,234 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| ZOETIS INC | CL A | 98978V103 | 8,682 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |