Authorized Person

0001053906-23-000006.txt : 20230512 0001053906-23-000006.hdr.sgml : 20230512 20230512122706 ACCESSION NUMBER: 0001053906-23-000006 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20230331 FILED AS OF DATE: 20230512 DATE AS OF CHANGE: 20230512 EFFECTIVENESS DATE: 20230512 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Artal Group S.A. CENTRAL INDEX KEY: 0001053906 IRS NUMBER: 000000000 STATE OF INCORPORATION: N4 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15027 FILM NUMBER: 23914314 BUSINESS ADDRESS: STREET 1: VALLEY PARK STREET 2: 44, RUE DE LA VALLEE CITY: LUXEMBOURG STATE: N4 ZIP: L-2661 BUSINESS PHONE: (352) 22.42.59-1 MAIL ADDRESS: STREET 1: VALLEY PARK STREET 2: 44, RUE DE LA VALLEE CITY: LUXEMBOURG STATE: N4 ZIP: L-2661 FORMER COMPANY: FORMER CONFORMED NAME: ARTAL GROUP S A DATE OF NAME CHANGE: 19980128 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false true false 0001053906 XXXXXXXX 03-31-2023 03-31-2023 false Artal Group S.A.

VALLEY PARK 44, RUE DE LA VALLEE LUXEMBOURG N4 L-2661

13F HOLDINGS REPORT 028-15027 Y The Reporting Manager does not have formal investment discretion with respect to all of the securities in the indicated rows in the Form 13F Information Table, but may be deemed to be part of a group exercising such investment discretion. Such group, if any, would include the managers identified in the column captioned "Other Managers" relating to a given issuer. The filing of this report shall not be deemed an admission, for purposes of Section 13(f), 13(d), 13(g), or 16(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the rules thereunder, or for any other purpose, that the Reporting Manager or any Other Manager exercises investment discretion or is a member of such a group with respect to such securities. Reference is made to reports filed under Sections 13(d), 13(g), and 16(a) for additional information with respect to such beneficial ownership and/or pecuniary interest of the Reporting Manager, any Other Manager and related entities. Anne Goffard Authorized Person 352224259-1 /s/ Anne Goffard Luxembourg N4 05-12-2023 6 120 1682919 1 0001460840 028-15028 Stichting Administratiekantoor Westend 2 0001283968 028-15029 Westend S.A. 3 0001522131 028-15031 Artal International Management S.A. 4 0001218180 028-15033 Artal International S.C.A. 5 0001340096 028-11522 Invus Public Equities Advisors, LLC 6 0001053905 028-19506 Artal Luxembourg S. A. INFORMATION TABLE 2 infotable.xml 23ANDME HOLDING CO CLASS A COM 90138Q108 1507 661009 SH DFND 1,2,3,4,5,6 661009 0 0 2SEVENTY BIO INC COMMON STOCK 901384107 7650 750000 SH DFND 1,2,3,4,5,6 750000 0 0 89BIO INC COM 282559103 7615 500000 SH DFND 1,2,3,4,5,6 500000 0 0 ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 2160 2255375 SH DFND 1,2,3,4,5,6 2255375 0 0 ADAGENE INC ADS 005329107 1450 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 AGENUS INC COM NEW 00847G705 23759 15631235 SH DFND 1,2,3,4,5,6 15631235 0 0 ALLOVIR INC COM 019818103 21974 5577167 SH DFND 1,2,3,4,5,6 5577167 0 0 ALPINE IMMUNE SCIENCES INC COM 02083G100 9210 1193030 SH DFND 1,2,3,4,5,6 1193030 0 0 ALX ONCOLOGY HLDGS INC COM 00166B105 2260 500000 SH DFND 1,2,3,4,5,6 500000 0 0 AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 6264 702291 SH DFND 1,2,3,4,5,6 702291 0 0 AMERICAN INTL GROUP INC COM NEW 026874784 201 4000 SH DFND 1,2,3,4,5,6 4000 0 0 AMICUS THERAPEUTICS INC COM 03152W109 39108 3526407 SH DFND 1,2,3,4,5,6 3526407 0 0 ANNEXON INC COM 03589W102 3920 1018303 SH DFND 1,2,3,4,5,6 1018303 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 80228 1216312 SH DFND 1,2,3,4,5,6 1216312 0 0 ARAVIVE INC COM 03890D108 9145 4572515 SH DFND 1,2,3,4,5,6 4572515 0 0 ARROWHEAD PHARMACEUTICALS IN COM 04280A100 665 26173 SH DFND 1,2,3,4,5,6 26173 0 0 ARVINAS INC COM 04335A105 495 18108 SH DFND 1,2,3,4,5,6 18108 0 0 AURINIA PHARMACEUTICALS INC COM 05156V102 10960 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 AVIDITY BIOSCIENCES INC COM 05370A108 7859 511962 SH DFND 1,2,3,4,5,6 511962 0 0 BANK AMERICA CORP COM 060505104 229 8000 SH DFND 1,2,3,4,5,6 8000 0 0 BEAM THERAPEUTICS INC COM 07373V105 336 10975 SH DFND 1,2,3,4,5,6 10975 0 0 BEIGENE LTD SPONSORED ADR 07725L102 108053 501335 SH DFND 1,2,3,4,5,6 501335 0 0 BIOCRYST PHARMACEUTICALS INC COM 09058V103 566 67909 SH DFND 1,2,3,4,5,6 67909 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 3108 31967 SH DFND 1,2,3,4,5,6 31967 0 0 BLACK DIAMOND THERAPEUTICS I COM 09203E105 3112 1646517 SH DFND 1,2,3,4,5,6 1646517 0 0 BRIDGEBIO PHARMA INC COM 10806X102 8290 500000 SH DFND 1,2,3,4,5,6 500000 0 0 CARIBOU BIOSCIENCES INC COM 142038108 559 105347 SH DFND 1,2,3,4,5,6 105347 0 0 CEREVEL THERAPEUTICS HLDNG I COM 15678U128 46694 1914466 SH DFND 1,2,3,4,5,6 1914466 0 0 CHINOOK THERAPEUTICS INC COM 16961L106 5989 258687 SH DFND 1,2,3,4,5,6 258687 0 0 CITIZENS FINL GROUP INC COM 174610105 152 5000 SH DFND 1,2,3,4,5,6 5000 0 0 CONTRAFECT CORP COM NEW 212326409 34 18750 SH DFND 1,2,3,4,5,6 18750 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 455 500000 SH DFND 1,2,3,4,5,6 500000 0 0 CULLINAN ONCOLOGY INC COM 230031106 2558 250000 SH DFND 1,2,3,4,5,6 250000 0 0 CURIS INC COM NEW 231269200 775 1300000 SH DFND 1,2,3,4,5,6 1300000 0 0 CYCLERION THERAPEUTICS INC COM 23255M105 1201 2768069 SH DFND 1,2,3,4,5,6 2768069 0 0 CYCLERION THERAPEUTICS INC COM 23255M105 5 11053 SH DFND 1,2,3,4 11053 0 0 CYTOKINETICS INC COM NEW 23282W605 48106 1367023 SH DFND 1,2,3,4,5,6 1367023 0 0 DENALI THERAPEUTICS INC COM 24823R105 18499 802899 SH DFND 1,2,3,4,5,6 802899 0 0 DICE THERAPEUTICS INC COM 23345J104 124 4318 SH DFND 1,2,3,4,5,6 4318 0 0 DYNE THERAPEUTICS INC COM 26818M108 6136 532609 SH DFND 1,2,3,4,5,6 532609 0 0 ERASCA INC COM 29479A108 14211 4721194 SH DFND 1,2,3,4,5,6 4721194 0 0 FATE THERAPEUTICS INC COM 31189P102 14820 2600000 SH DFND 1,2,3,4,5,6 2600000 0 0 FOGHORN THERAPEUTICS INC COM 344174107 10668 1720720 SH DFND 1,2,3,4,5,6 1720720 0 0 FUSION PHARMACEUTICALS INC COM 36118A100 7446 1975000 SH DFND 1,2,3,4,5,6 1975000 0 0 GENERATION BIO CO COM 37148K100 12101 2814191 SH DFND 1,2,3,4,5,6 2814191 0 0 GERON CORP COM 374163103 12078 5565889 SH DFND 1,2,3,4,5,6 5565889 0 0 GLYCOMIMETICS INC COM 38000Q102 10822 8589064 SH DFND 1,2,3,4,5,6 8589064 0 0 GOSSAMER BIO INC COM 38341P102 3815 3028171 SH DFND 1,2,3,4,5,6 3028171 0 0 HARPOON THERAPEUTICS INC COM 41358P106 744 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 HIPPO HLDGS INC COM NEW 433539202 390 24000 SH DFND 1,2,3,4,5,6 24000 0 0 HOOKIPA PHARMA INC COM 43906K100 1361 1849616 SH DFND 1,2,3,4,5,6 1849616 0 0 IGM BIOSCIENCES INC COM 449585108 34487 2509972 SH DFND 1,2,3,4,5,6 2509972 0 0 IKENA ONCOLOGY INC COM 45175G108 5346 1549513 SH DFND 1,2,3,4,5,6 1549513 0 0 I MAB SPONSORED ADS 44975P103 2941 850000 SH DFND 1,2,3,4,5,6 850000 0 0 IMMUNIC INC COM 4525EP101 1899 1274713 SH DFND 1,2,3,4,5,6 1274713 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 10289 276077 SH DFND 1,2,3,4,5,6 276077 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1163 110532 SH DFND 1,2,3,4 110532 0 0 ITEOS THERAPEUTICS INC COM 46565G104 5444 400000 SH DFND 1,2,3,4,5,6 400000 0 0 KARUNA THERAPEUTICS INC COM 48576A100 317 1747 SH DFND 1,2,3,4,5,6 1747 0 0 KE HLDGS INC SPONSORED ADS 482497104 5181 275000 SH DFND 1,2,3,4,5,6 275000 0 0 KINETA INC COM 49461C102 103 31055 SH DFND 1,2,3,4,5,6 31055 0 0 KINNATE BIOPHARMA INC COM 49705R105 781 125000 SH DFND 1,2,3,4,5,6 125000 0 0 KRONOS BIO INC COM 50107A104 2253 1542954 SH DFND 1,2,3,4,5,6 1542954 0 0 KRYSTAL BIOTECH INC COM 501147102 32991 412082 SH DFND 1,2,3,4,5,6 412082 0 0 KURA ONCOLOGY INC COM 50127T109 21012 1718056 SH DFND 1,2,3,4,5,6 1718056 0 0 KYMERA THERAPEUTICS INC COM 501575104 53492 1805346 SH DFND 1,2,3,4,5,6 1805346 0 0 LAVA THERAPEUTICS NV SHS N51517105 332 200000 SH DFND 1,2,3,4,5,6 200000 0 0 LEAP THERAPEUTICS INC COM 52187K101 1360 4000000 SH DFND 1,2,3,4,5,6 4000000 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 8544 3516214 SH DFND 1,2,3,4,5,6 3516214 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 209617 86262020 SH DFND 1,2,3,4 67662150 0 0 MERSANA THERAPEUTICS INC COM 59045L106 9107 2215788 SH DFND 1,2,3,4,5,6 2215788 0 0 METACRINE INC COM 59101E103 528 924898 SH DFND 1,2,3,4,5,6 924898 0 0 MINK THERAPEUTICS INC COM 603693102 549 289588 SH DFND 1,2,3,4,5,6 289588 0 0 MIRATI THERAPEUTICS INC COM 60468T105 57172 1537709 SH DFND 1,2,3,4,5,6 1537709 0 0 MORPHIC HLDG INC COM 61775R105 68277 1813949 SH DFND 1,2,3,4,5,6 1813949 0 0 NANOBIOTIX SPONSORED ADS 63009J107 3525 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 NATERA INC COM 632307104 11104 200000 SH DFND 1,2,3,4,5,6 200000 0 0 OMEGA THERAPEUTICS INC COM 68217N105 15274 2533045 SH DFND 1,2,3,4,5,6 2533045 0 0 OVID THERAPEUTICS INC COM 690469101 6450 2500000 SH DFND 1,2,3,4,5,6 2500000 0 0 PLIANT THERAPEUTICS INC COM 729139105 6785 255085 SH DFND 1,2,3,4,5,6 255085 0 0 PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106 3891 380000 SH DFND 1,2,3,4,5,6 380000 0 0 PROMETHEUS BIOSCIENCES INC COM 74349U108 13067 121756 SH DFND 1,2,3,4,5,6 121756 0 0 PROTHENA CORP PLC SHS G72800108 133 2746 SH DFND 1,2,3,4,5,6 2746 0 0 RELAY THERAPEUTICS INC COM 75943R102 27567 1673743 SH DFND 1,2,3,4,5,6 1673743 0 0 REPARE THERAPEUTICS INC COM 760273102 6888 700000 SH DFND 1,2,3,4,5,6 700000 0 0 REPLIMUNE GROUP INC COM 76029N106 8830 500000 SH DFND 1,2,3,4,5,6 500000 0 0 REVOLUTION MEDICINES INC COM 76155X100 44858 2070988 SH DFND 1,2,3,4,5,6 2070988 0 0 ROIVANT SCIENCES LTD SHS G76279101 4428 600000 SH DFND 1,2,3,4,5,6 600000 0 0 RUBIUS THERAPEUTICS INC COM 78116T103 44 2042666 SH DFND 1,2,3,4,5,6 2042666 0 0 SAGE THERAPEUTICS INC COM 78667J108 31470 750000 SH DFND 1,2,3,4,5,6 750000 0 0 SANA BIOTECHNOLOGY INC COM 799566104 1308 400000 SH DFND 1,2,3,4,5,6 400000 0 0 SCHOLAR ROCK HLDG CORP COM 80706P103 72224 9027950 SH DFND 1,2,3,4,5,6 9027950 0 0 SCHRODINGER INC COM 80810D103 18431 700000 SH DFND 1,2,3,4,5,6 700000 0 0 SEA LTD SPONSORED ADS 81141R100 26181 302500 SH DFND 1,2,3,4,5,6 302500 0 0 SEER INC COM CL A 81578P106 18335 4750000 SH DFND 1,2,3,4,5,6 4750000 0 0 SELECTA BIOSCIENCES INC COM 816212104 6788 4883200 SH DFND 1,2,3,4,5,6 4883200 0 0 SENTI BIOSCIENCES INC COM 81726A100 66 55555 SH DFND 1,2,3,4,5,6 55555 0 0 SILENCE THERAPEUTICS PLC ADS 82686Q101 3131 505074 SH DFND 1,2,3,4,5,6 505074 0 0 SOLID BIOSCIENCES INC COM NEW 83422E204 4310 909219 SH DFND 1,2,3,4,5,6 909219 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 46779 1817349 SH DFND 1,2,3,4,5,6 1817349 0 0 SQZ BIOTECHNOLOGIES CO COM 78472W104 900 1606309 SH DFND 1,2,3,4,5,6 1606309 0 0 STOKE THERAPEUTICS INC COM 86150R107 2083 250000 SH DFND 1,2,3,4,5,6 250000 0 0 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 1784 75000 SH DFND 1,2,3,4,5,6 75000 0 0 SYROS PHARMACEUTICALS INC COM NEW 87184Q206 3940 1475744 SH DFND 1,2,3,4,5,6 1475744 0 0 TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2791 30000 SH DFND 1,2,3,4,5,6 30000 0 0 TALARIS THERAPEUTICS INC COM 87410C104 1719 914262 SH DFND 1,2,3,4,5,6 914262 0 0 TAYSHA GENE THERAPIES INC COM SHS 877619106 1149 1440882 SH DFND 1,2,3,4,5,6 1440882 0 0 TCR2 THERAPEUTICS INC COM 87808K106 1125 750000 SH DFND 1,2,3,4,5,6 750000 0 0 TG THERAPEUTICS INC COM 88322Q108 7691 511389 SH DFND 1,2,3,4,5,6 511389 0 0 TRAVERE THERAPEUTICS INC COM 89422G107 11510 511784 SH DFND 1,2,3,4,5,6 511784 0 0 UNITED THERAPEUTICS CORP COM 91307C102 735 3281 SH DFND 1,2,3,4,5,6 3281 0 0 VENTYX BIOSCIENCES INC COM 92332V107 17950 535812 SH DFND 1,2,3,4,5,6 535812 0 0 VERVE THERAPEUTICS INC COM 92539P101 4326 300000 SH DFND 1,2,3,4,5,6 300000 0 0 VIGIL NEUROSCIENCE INC COM 92673K108 21962 2243352 SH DFND 1,2,3,4,5,6 2243352 0 0 VIKING THERAPEUTICS INC COM 92686J106 4995 300000 SH DFND 1,2,3,4,5,6 300000 0 0 VIRIDIAN THERAPEUTICS INC COM 92790C104 12847 504978 SH DFND 1,2,3,4,5,6 504978 0 0 VOR BIOPHARMA INC COM 929033108 15025 2792805 SH DFND 1,2,3,4,5,6 2792805 0 0 WAVE LIFE SCIENCES LTD SHS Y95308105 12990 3000000 SH DFND 1,2,3,4,5,6 3000000 0 0 WW INTL INC COM 98262P101 61051 14818300 SH DFND 1,2,3,4,6 14818300 0 0 XILIO THERAPEUTICS INC COM 98422T100 1427 450000 SH DFND 1,2,3,4,5,6 450000 0 0