Authorized Person

0001053906-22-000011.txt : 20221114 0001053906-22-000011.hdr.sgml : 20221114 20221114094536 ACCESSION NUMBER: 0001053906-22-000011 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20220930 FILED AS OF DATE: 20221114 DATE AS OF CHANGE: 20221114 EFFECTIVENESS DATE: 20221114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Artal Group S.A. CENTRAL INDEX KEY: 0001053906 IRS NUMBER: 000000000 STATE OF INCORPORATION: N4 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15027 FILM NUMBER: 221381380 BUSINESS ADDRESS: STREET 1: VALLEY PARK STREET 2: 44, RUE DE LA VALLEE CITY: LUXEMBOURG STATE: N4 ZIP: L-2661 BUSINESS PHONE: (352) 22.42.59-1 MAIL ADDRESS: STREET 1: VALLEY PARK STREET 2: 44, RUE DE LA VALLEE CITY: LUXEMBOURG STATE: N4 ZIP: L-2661 FORMER COMPANY: FORMER CONFORMED NAME: ARTAL GROUP S A DATE OF NAME CHANGE: 19980128 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001053906 XXXXXXXX 09-30-2022 09-30-2022 false Artal Group S.A.

VALLEY PARK 44, RUE DE LA VALLEE LUXEMBOURG N4 L-2661

13F HOLDINGS REPORT 028-15027 Y The Reporting Manager does not have formal investment discretion with respect to all of the securities in the indicated rows in the Form 13F Information Table, but may be deemed to be part of a group exercising such investment discretion. Such group, if any, would include the managers identified in the column captioned "Other Managers" relating to a given issuer. The filing of this report shall not be deemed an admission, for purposes of Section 13(f), 13(d), 13(g), or 16(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the rules thereunder, or for any other purpose, that the Reporting Manager or any Other Manager exercises investment discretion or is a member of such a group with respect to such securities. Reference is made to reports filed under Sections 13(d), 13(g), and 16(a) for additional information with respect to such beneficial ownership and/or pecuniary interest of the Reporting Manager, any Other Manager and related entities. Anne Goffard Authorized Person 352224259-1 /s/ Anne Goffard Luxembourg N4 11-14-2022 6 137 2343188 1 0001460840 028-15028 Stichting Administratiekantoor Westend 2 0001283968 028-15029 Westend S.A. 3 0001522131 028-15031 Artal International Management S.A. 4 0001218180 028-15033 Artal International S.C.A. 5 0001340096 028-11522 Invus Public Equities Advisors, LLC 6 0001053905 028-19506 Artal Luxembourg S. A. INFORMATION TABLE 2 infotable.xml 111 INC ADS 68247Q102 1840 686431 SH DFND 1,2,3,4,5,6 686431 0 0 23ANDME HOLDING CO CLASS A COM 90138Q108 1890 661009 SH DFND 1,2,3,4,5,6 661009 0 0 AC IMMUNE SA SHS H00263105 3160 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 5097 2255375 SH DFND 1,2,3,4,5,6 2255375 0 0 ADAGENE INC ADS 005329107 1280 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 ADOBE SYSTEMS INCORPORATED COM 00724F101 358 1300 SH DFND 1,2,3,4,5,6 1300 0 0 AGENUS INC COM NEW 00847G705 8200 4000000 SH DFND 1,2,3,4,5,6 4000000 0 0 ALLOVIR INC COM 019818103 44004 5577167 SH DFND 1,2,3,4,5,6 5577167 0 0 ALPINE IMMUNE SCIENCES INC COM 02083G100 8590 1193030 SH DFND 1,2,3,4,5,6 1193030 0 0 ALX ONCOLOGY HLDGS INC COM 00166B105 4785 500000 SH DFND 1,2,3,4,5,6 500000 0 0 AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 2324 2152291 SH DFND 1,2,3,4,5,6 2152291 0 0 AMICUS THERAPEUTICS INC COM 03152W109 41760 4000000 SH DFND 1,2,3,4,5,6 4000000 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 68300 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 APPLIED THERAPEUTICS INC COM 03828A101 372 400000 SH DFND 1,2,3,4,5,6 400000 0 0 APTINYX INC COM 03836N103 2251 6116493 SH DFND 1,2,3,4,5,6 6116493 0 0 ARAVIVE INC COM 03890D108 1072 1311291 SH DFND 1,2,3,4,5,6 1311291 0 0 ARGENX SE SPONSORED ADR 04016X101 52958 150000 SH DFND 1,2,3,4,5,6 150000 0 0 ASTRIA THERAPEUTICS INC COM 04635X102 301 33333 SH DFND 1,2,3,4,5,6 33333 0 0 AURINIA PHARMACEUTICALS INC COM 05156V102 7520 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 AVANTOR INC COM 05352A100 882 45000 SH DFND 1,2,3,4,5,6 45000 0 0 AVIDITY BIOSCIENCES INC COM 05370A108 4083 250000 SH DFND 1,2,3,4,5,6 250000 0 0 AXCELLA HEALTH INC COM 05454B105 1218 712500 SH DFND 1,2,3,4,5,6 712500 0 0 BEIGENE LTD SPONSORED ADR 07725L102 87633 650000 SH DFND 1,2,3,4,5,6 650000 0 0 BEIGENE LTD SPONSORED ADR 07725L102 6741 50000 SH Call DFND 1,2,3,4,5,6 50000 0 0 BELLUS HEALTH INC NEW COM NEW 07987C204 63360 6000000 SH DFND 1,2,3,4,5,6 6000000 0 0 BLACK DIAMOND THERAPEUTICS I COM 09203E105 2783 1646517 SH DFND 1,2,3,4,5,6 1646517 0 0 BRIDGEBIO PHARMA INC COM 10806X102 2485 250000 SH DFND 1,2,3,4,5,6 250000 0 0 CARDIFF ONCOLOGY INC COM 14147L108 1155 750000 SH DFND 1,2,3,4,5,6 750000 0 0 CARIBOU BIOSCIENCES INC COM 142038108 1111 105347 SH DFND 1,2,3,4,5,6 105347 0 0 CEREVEL THERAPEUTICS HLDNG I COM 15678U128 56520 2000000 SH DFND 1,2,3,4,5,6 2000000 0 0 CIDARA THERAPEUTICS INC COM 171757107 141 224675 SH DFND 1,2,3,4,5,6 224675 0 0 CODIAK BIOSCIENCES INC COM 192010106 156 200000 SH DFND 1,2,3,4,5,6 200000 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 3840 573062 SH DFND 1,2,3,4,5,6 573062 0 0 CONTRAFECT CORP COM NEW 212326300 252 1500000 SH DFND 1,2,3,4,5,6 1500000 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 409 500000 SH DFND 1,2,3,4,5,6 500000 0 0 CULLINAN ONCOLOGY INC COM 230031106 3205 250000 SH DFND 1,2,3,4,5,6 250000 0 0 CURIS INC COM NEW 231269200 910 1300000 SH DFND 1,2,3,4,5,6 1300000 0 0 CYCLERION THERAPEUTICS INC COM 23255M105 2381 2768069 SH DFND 1,2,3,4,5,6 2768069 0 0 CYCLERION THERAPEUTICS INC COM 23255M105 10 11053 SH DFND 1,2,3,4 11053 0 0 CYTOKINETICS INC COM NEW 23282W605 48450 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 DENALI THERAPEUTICS INC COM 24823R105 18414 600000 SH DFND 1,2,3,4,5,6 600000 0 0 DYNE THERAPEUTICS INC COM 26818M108 6668 525000 SH DFND 1,2,3,4,5,6 525000 0 0 EQRX INC COM 26886C107 19800 4000000 SH DFND 1,2,3,4,5,6 4000000 0 0 ERASCA INC COM 29479A108 24743 3172221 SH DFND 1,2,3,4,5,6 3172221 0 0 EVOTEC AG SPONSORED ADS 30050E105 10103 1149425 SH DFND 1,2,3,4,5,6 1149425 0 0 EXSCIENTIA PLC ADS 30223G102 4516 550000 SH DFND 1,2,3,4,5,6 550000 0 0 FATE THERAPEUTICS INC COM 31189P102 58266 2600000 SH DFND 1,2,3,4,5,6 2600000 0 0 FOGHORN THERAPEUTICS INC COM 344174107 14764 1720720 SH DFND 1,2,3,4,5,6 1720720 0 0 FUSION PHARMACEUTICALS INC COM 36118A100 2258 750000 SH DFND 1,2,3,4,5,6 750000 0 0 GENERATION BIO CO COM 37148K100 14943 2814191 SH DFND 1,2,3,4,5,6 2814191 0 0 GOSSAMER BIO INC COM 38341P102 38895 3246624 SH DFND 1,2,3,4,5,6 3246624 0 0 GRAPHITE BIO INC COM 38870X104 2219 700000 SH DFND 1,2,3,4,5,6 700000 0 0 GRITSTONE BIO INC COM 39868T105 1928 750000 SH DFND 1,2,3,4,5,6 750000 0 0 HARPOON THERAPEUTICS INC COM 41358P106 970 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 HIPPO HLDGS INC COM NEW 433539202 445 24000 SH DFND 1,2,3,4,5,6 24000 0 0 HOOKIPA PHARMA INC COM 43906K100 2478 1849616 SH DFND 1,2,3,4,5,6 1849616 0 0 IGM BIOSCIENCES INC COM 449585108 55713 2450000 SH DFND 1,2,3,4,5,6 2450000 0 0 IGM BIOSCIENCES INC COM 449585108 1137 50000 SH Call DFND 1,2,3,4,5,6 50000 0 0 IKENA ONCOLOGY INC COM 45175G108 5501 1549513 SH DFND 1,2,3,4,5,6 1549513 0 0 I MAB SPONSORED ADS 44975P103 3409 850000 SH DFND 1,2,3,4,5,6 850000 0 0 IMMUNIC INC COM 4525EP101 2212 700000 SH DFND 1,2,3,4,5,6 700000 0 0 IMMUTEP LTD SPONSORED ADS 45257L108 1560 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 INSTIL BIO INC COM 45783C101 2178 450000 SH DFND 1,2,3,4,5,6 450000 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 15389 275000 SH DFND 1,2,3,4,5,6 275000 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1145 110532 SH DFND 1,2,3,4 110532 0 0 ITEOS THERAPEUTICS INC COM 46565G104 7620 400000 SH DFND 1,2,3,4,5,6 400000 0 0 IVERIC BIO INC COM 46583P102 13455 750000 SH DFND 1,2,3,4,5,6 750000 0 0 IVERIC BIO INC COM 46583P102 8970 500000 SH Call DFND 1,2,3,4,5,6 500000 0 0 KARUNA THERAPEUTICS INC COM 48576A100 28116 125000 SH DFND 1,2,3,4,5,6 125000 0 0 KINNATE BIOPHARMA INC COM 49705R105 1494 125000 SH DFND 1,2,3,4,5,6 125000 0 0 KRONOS BIO INC COM 50107A104 5169 1542954 SH DFND 1,2,3,4,5,6 1542954 0 0 KRYSTAL BIOTECH INC COM 501147102 34850 500000 SH DFND 1,2,3,4,5,6 500000 0 0 KURA ONCOLOGY INC COM 50127T109 15026 1100000 SH DFND 1,2,3,4,5,6 1100000 0 0 KYMERA THERAPEUTICS INC COM 501575104 32655 1500000 SH DFND 1,2,3,4,5,6 1500000 0 0 LAVA THERAPEUTICS NV SHS N51517105 914 200000 SH DFND 1,2,3,4,5,6 200000 0 0 LEAP THERAPEUTICS INC COM 52187K101 3520 4000000 SH DFND 1,2,3,4,5,6 4000000 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 8439 3516214 SH DFND 1,2,3,4,5,6 3516214 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 207029 86262020 SH DFND 1,2,3,4 86262020 0 0 LYELL IMMUNOPHARMA INC COM 55083R104 5131 700000 SH DFND 1,2,3,4,5,6 700000 0 0 MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 1044 157000 SH DFND 1,2,3,4,5,6 157000 0 0 MEI PHARMA INC COM NEW 55279B202 387 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 1292 1500000 SH DFND 1,2,3,4,5,6 1500000 0 0 MERSANA THERAPEUTICS INC COM 59045L106 14872 2200000 SH DFND 1,2,3,4,5,6 2200000 0 0 METACRINE INC COM 59101E103 449 924898 SH DFND 1,2,3,4,5,6 924898 0 0 MINERVA NEUROSCIENCES INC COM NEW 603380205 2308 250000 SH DFND 1,2,3,4,5,6 250000 0 0 MINK THERAPEUTICS INC COM 603693102 611 289588 SH DFND 1,2,3,4,5,6 289588 0 0 MIRATI THERAPEUTICS INC COM 60468T105 92538 1325000 SH DFND 1,2,3,4,5,6 1325000 0 0 MIRION TECHNOLOGIES INC COM CL A 60471A101 3735 500000 SH DFND 1,2,3,4,5,6 500000 0 0 MORPHIC HLDG INC COM 61775R105 60845 2150000 SH DFND 1,2,3,4,5,6 2150000 0 0 NANOBIOTIX SPONSORED ADS 63009J107 3540 1000000 SH DFND 1,2,3,4,5,6 1000000 0 0 NATERA INC COM 632307104 4382 100000 SH DFND 1,2,3,4,5,6 100000 0 0 NEXIMMUNE INC COM 65344D109 666 1200000 SH DFND 1,2,3,4,5,6 1200000 0 0 OATLY GROUP AB SPONSORED ADS 67421J108 3945 1500000 SH DFND 1,2,3,4,5,6 1500000 0 0 OLEMA PHARMACEUTICALS INC COM 68062P106 719 260500 SH DFND 1,2,3,4,5,6 260500 0 0 OMEGA ALPHA SPAC CL A G6749V107 7448 750000 SH DFND 1,2,3,4,5,6 750000 0 0 OMEGA THERAPEUTICS INC COM 68217N105 12323 2273530 SH DFND 1,2,3,4,5,6 2273530 0 0 ORCHARD THERAPEUTICS PLC SPON ADS 68570P101 902 1803858 SH DFND 1,2,3,4,5,6 1803858 0 0 ORIC PHARMACEUTICALS INC COM 68622P109 1280 400000 SH DFND 1,2,3,4,5,6 400000 0 0 OVID THERAPEUTICS INC COM 690469101 4600 2500000 SH DFND 1,2,3,4,5,6 2500000 0 0 PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106 3713 380000 SH DFND 1,2,3,4,5,6 380000 0 0 PRAXIS PRECISION MEDICINES I COM 74006W108 2724 1200000 SH DFND 1,2,3,4,5,6 1200000 0 0 RECURSION PHARMACEUTICALS IN CL A 75629V104 4788 450000 SH DFND 1,2,3,4,5,6 450000 0 0 RELAY THERAPEUTICS INC COM 75943R102 32542 1454716 SH DFND 1,2,3,4,5,6 1454716 0 0 REPARE THERAPEUTICS INC COM 760273102 8491 700000 SH DFND 1,2,3,4,5,6 700000 0 0 REPLIMUNE GROUP INC COM 76029N106 15543 900000 SH DFND 1,2,3,4,5,6 900000 0 0 RUBIUS THERAPEUTICS INC COM 78116T103 886 2042666 SH DFND 1,2,3,4,5,6 2042666 0 0 SAGE THERAPEUTICS INC COM 78667J108 29370 750000 SH DFND 1,2,3,4,5,6 750000 0 0 SANA BIOTECHNOLOGY INC COM 799566104 2400 400000 SH DFND 1,2,3,4,5,6 400000 0 0 SCHOLAR ROCK HLDG CORP COM 80706P103 60638 8750034 SH DFND 1,2,3,4,5,6 8750034 0 0 SCHRODINGER INC COM 80810D103 17486 700000 SH DFND 1,2,3,4,5,6 700000 0 0 SEA LTD SPONSORED ADS 81141R100 9669 172500 SH DFND 1,2,3,4,5,6 172500 0 0 SEAGEN INC COM 81181C104 47891 350000 SH DFND 1,2,3,4,5,6 350000 0 0 SEAGEN INC COM 81181C104 13683 100000 SH Call DFND 1,2,3,4,5,6 100000 0 0 SEER INC COM CL A 81578P106 36765 4750000 SH DFND 1,2,3,4,5,6 4750000 0 0 SELECTA BIOSCIENCES INC COM 816212104 8008 4883200 SH DFND 1,2,3,4,5,6 4883200 0 0 SENTI BIOSCIENCES INC COM 81726A100 2291 1055555 SH DFND 1,2,3,4,5,6 1055555 0 0 SIGILON THERAPEUTICS INC COM 82657L107 139 276000 SH DFND 1,2,3,4,5,6 276000 0 0 SOLID BIOSCIENCES INC COM 83422E105 1400 3000000 SH DFND 1,2,3,4,5,6 3000000 0 0 SPDR SER TR S&P BIOTECH 78464A870 396600 5000000 SH Call DFND 1,2,3,4,5,6 5000000 0 0 SPERO THERAPEUTICS INC COM 84833T103 1000 500000 SH DFND 1,2,3,4,5,6 500000 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 58584 2053403 SH DFND 1,2,3,4,5,6 2053403 0 0 SQZ BIOTECHNOLOGIES CO COM 78472W104 3662 1606309 SH DFND 1,2,3,4,5,6 1606309 0 0 STOKE THERAPEUTICS INC COM 86150R107 3210 250000 SH DFND 1,2,3,4,5,6 250000 0 0 SYROS PHARMACEUTICALS INC COM NEW 87184Q206 9427 1463829 SH DFND 1,2,3,4,5,6 1463829 0 0 TALARIS THERAPEUTICS INC COM 87410C104 5429 2064262 SH DFND 1,2,3,4,5,6 2064262 0 0 TAYSHA GENE THERAPIES INC COM SHS 877619106 2009 1040882 SH DFND 1,2,3,4,5,6 1040882 0 0 TCR2 THERAPEUTICS INC COM 87808K106 1350 750000 SH DFND 1,2,3,4,5,6 750000 0 0 THIRD HARMONIC BIO INC COM 88427A107 3794 200000 SH DFND 1,2,3,4,5,6 200000 0 0 VERVE THERAPEUTICS INC COM 92539P101 13740 400000 SH DFND 1,2,3,4,5,6 400000 0 0 VIGIL NEUROSCIENCE INC COM 92673K108 20799 2285574 SH DFND 1,2,3,4,5,6 2285574 0 0 VOR BIOPHARMA INC COM 929033108 2189 550000 SH DFND 1,2,3,4,5,6 550000 0 0 WAVE LIFE SCIENCES LTD SHS Y95308105 10830 3000000 SH DFND 1,2,3,4,5,6 3000000 0 0 WW INTL INC COM 98262P101 58236 14818300 SH DFND 1,2,3,4,6 14818300 0 0 XILIO THERAPEUTICS INC COM 98422T100 1310 450000 SH DFND 1,2,3,4,5,6 450000 0 0 Y-MABS THERAPEUTICS INC COM 984241109 5768 400000 SH DFND 1,2,3,4,5,6 400000 0 0 YUMANITY THERAPEUTICS INC COM 98872L102 341 217391 SH DFND 1,2,3,4,5,6 217391 0 0 ZYMEWORKS INC COM 98985W102 2768 450000 SH DFND 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