The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 1,991 966,349 SH   DFND 1,2,3,4,5,6 966,349 0 0
23ANDME HOLDING CO CLASS A COM 90138Q108 1,639 661,009 SH   DFND 1,2,3,4,5,6 661,009 0 0
AC IMMUNE SA SHS H00263105 3,610 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 5,684 2,255,375 SH   DFND 1,2,3,4,5,6 2,255,375 0 0
ADAGENE INC ADS 005329107 2,066 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ADAGIO THERAPEUTICS INC COM 00534A102 3,280 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 3,600 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
AGENUS INC COM NEW 00847G705 5,820 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
ALLOVIR INC COM 019818103 9,061 2,323,371 SH   DFND 1,2,3,4,5,6 2,323,371 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 87,510 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 5,047 593,030 SH   DFND 1,2,3,4,5,6 593,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 4,045 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 5,704 2,152,291 SH   DFND 1,2,3,4,5,6 2,152,291 0 0
AMICUS THERAPEUTICS INC COM 03152W109 42,960 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 1,445 75,000 SH   DFND 1,2,3,4,5,6 75,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101 379 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
APTINYX INC COM 03836N103 3,412 6,116,493 SH   DFND 1,2,3,4,5,6 6,116,493 0 0
ARAVIVE INC COM 03890D108 1,295 1,311,291 SH   DFND 1,2,3,4,5,6 1,311,291 0 0
ARGENX SE SPONSORED ADR 04016X101 151,552 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 100 33,333 SH   DFND 1,2,3,4,5,6 33,333 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 7,790 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 10,050 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 3,633 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
AXCELLA HEALTH INC COM 05454B105 1,446 712,500 SH   DFND 1,2,3,4,5,6 712,500 0 0
BATH & BODY WORKS INC COM 070830104 337 12,500 SH   DFND 1,2,3,4,5,6 12,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 105,203 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 64,680 7,000,000 SH   DFND 1,2,3,4,5,6 7,000,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 4,050 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BRIDGEBIO PHARMA INC COM 10806X102 2,270 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CARDIFF ONCOLOGY INC COM 14147L108 1,650 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
CARIBOU BIOSCIENCES INC COM 142038108 572 105,347 SH   DFND 1,2,3,4,5,6 105,347 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 39,660 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CIDARA THERAPEUTICS INC COM 171757107 110 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CINCOR PHARMA INC COM 17240Y109 2,581 137,010 SH   DFND 1,2,3,4,5,6 137,010 0 0
CITIGROUP INC COM NEW 172967424 45,990 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
CLEVELAND-CLIFFS INC NEW COM 185899101 384 25,000 SH   DFND 1,2,3,4,5,6 25,000 0 0
CODIAK BIOSCIENCES INC COM 192010106 576 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CONTRAFECT CORP COM NEW 212326300 4,605 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 495 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 3,205 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CURIS INC COM NEW 231269200 1,280 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 1,519 2,768,069 SH   DFND 1,2,3,4,5,6 2,768,069 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 6 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYTOKINETICS INC COM NEW 23282W605 50,095 1,275,000 SH   DFND 1,2,3,4,5,6 1,275,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 17,658 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 5,600 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DIREXION SHS ETF TR SP BIOTCH BL NEW 25490K323 26,960 4,000,000 SH Call DFND 1,2,3,4,5,6 4,000,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 3,607 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
EQRX INC COM 26886C107 18,760 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
ERASCA INC COM 29479A108 17,669 3,172,221 SH   DFND 1,2,3,4,5,6 3,172,221 0 0
EVOTEC AG SPONSORED ADS 30050E105 13,770 1,149,425 SH   DFND 1,2,3,4,5,6 1,149,425 0 0
EXSCIENTIA PLC ADS 30223G102 5,990 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
FATE THERAPEUTICS INC COM 31189P102 64,428 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 23,402 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 1,868 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
GENERATION BIO CO COM 37148K100 18,461 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOSSAMER BIO INC COM 38341P102 19,745 2,358,968 SH   DFND 1,2,3,4,5,6 2,358,968 0 0
GRAPHITE BIO INC COM 38870X104 1,925 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
GRITSTONE BIO INC COM 39868T105 1,815 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 1,910 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
HIPPO HLDGS INC COM 433539103 527 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
HOOKIPA PHARMA INC COM 43906K100 3,015 1,849,616 SH   DFND 1,2,3,4,5,6 1,849,616 0 0
IGM BIOSCIENCES INC COM 449585108 36,060 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
IGM BIOSCIENCES INC COM 449585108 902 50,000 SH Call DFND 1,2,3,4,5,6 50,000 0 0
IKENA ONCOLOGY INC COM 45175G108 6,864 1,549,513 SH   DFND 1,2,3,4,5,6 1,549,513 0 0
I MAB SPONSORED ADS 44975P103 9,605 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
IMMUNIC INC COM 4525EP101 2,429 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 2,030 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
INSTIL BIO INC COM 45783C101 2,079 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 14,234 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,274 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104 8,240 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
KALEIDO BIOSCIENCES INC COM 483347100 31 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KINNATE BIOPHARMA INC COM 49705R105 1,576 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104 5,616 1,542,954 SH   DFND 1,2,3,4,5,6 1,542,954 0 0
KRYSTAL BIOTECH INC COM 501147102 32,830 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
KURA ONCOLOGY INC COM 50127T109 19,247 1,050,000 SH   DFND 1,2,3,4,5,6 1,050,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 19,690 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 590 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 4,600 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 6,540 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 125,852 67,662,150 SH   DFND 1,2,3,4 67,662,150 0 0
LYELL IMMUNOPHARMA INC COM 55083R104 4,564 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 4,840 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEI PHARMA INC COM NEW 55279B202 605 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 1,680 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 10,164 2,200,000 SH   DFND 1,2,3,4,5,6 2,200,000 0 0
METACRINE INC COM 59101E103 462 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MINK THERAPEUTICS INC COM 603693102 408 289,588 SH   DFND 1,2,3,4,5,6 289,588 0 0
MIRATI THERAPEUTICS INC COM 60468T105 73,843 1,100,000 SH   DFND 1,2,3,4,5,6 1,100,000 0 0
MIRION TECHNOLOGIES INC COM CL A 60471A101 2,880 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MORPHIC HLDG INC COM 61775R105 35,805 1,650,000 SH   DFND 1,2,3,4,5,6 1,650,000 0 0
NANOBIOTIX SPONSORED ADS 63009J107 3,800 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NEXIMMUNE INC COM 65344D109 1,932 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
OATLY GROUP AB SPONSORED ADS 67421J108 5,190 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 1,060 260,500 SH   DFND 1,2,3,4,5,6 260,500 0 0
OMEGA ALPHA SPAC CL A G6749V107 7,388 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
OMEGA THERAPEUTICS INC COM 68217N105 8,639 2,273,530 SH   DFND 1,2,3,4,5,6 2,273,530 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,054 1,803,858 SH   DFND 1,2,3,4,5,6 1,803,858 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 1,792 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
OVID THERAPEUTICS INC COM 690469101 5,375 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106 3,705 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 2,940 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104 3,663 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 11,725 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
REPARE THERAPEUTICS INC COM 760273102 9,793 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
REPLIMUNE GROUP INC COM 76029N106 15,732 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 3,149 3,701,580 SH   DFND 1,2,3,4,5,6 3,701,580 0 0
SAGE THERAPEUTICS INC COM 78667J108 14,535 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104 2,572 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 48,038 8,750,034 SH   DFND 1,2,3,4,5,6 8,750,034 0 0
SCHRODINGER INC COM 80810D103 18,487 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
SEA LTD SPONSORED ADS 81141R100 3,844 57,500 SH   DFND 1,2,3,4,5,6 57,500 0 0
SEAGEN INC COM 81181C104 92,894 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
SEER INC COM CL A 81578P106 42,513 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 6,397 4,883,200 SH   DFND 1,2,3,4,5,6 4,883,200 0 0
SENTI BIOSCIENCES INC COM 81726A100 2,074 1,055,555 SH   DFND 1,2,3,4,5,6 1,055,555 0 0
SIGILON THERAPEUTICS INC COM 82657L107 229 276,000 SH   DFND 1,2,3,4,5,6 276,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 1,847 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 371 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 22,158 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104 5,108 1,606,309 SH   DFND 1,2,3,4,5,6 1,606,309 0 0
STOKE THERAPEUTICS INC COM 86150R107 3,303 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 3,851 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
TALARIS THERAPEUTICS INC COM 87410C104 9,310 2,064,262 SH   DFND 1,2,3,4,5,6 2,064,262 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 3,872 1,040,882 SH   DFND 1,2,3,4,5,6 1,040,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106 2,175 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
UNITED STS NAT GAS FD LP UNIT PAR 912318300 380 20,000 SH   DFND 1,2,3,4,5,6 20,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 6,112 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 2,893 1,121,191 SH   DFND 1,2,3,4,5,6 1,121,191 0 0
VOR BIOPHARMA INC COM 929033108 2,734 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 9,750 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
WW INTL INC COM 98262P101 94,689 14,818,300 SH   DFND 1,2,3,4,6 14,818,300 0 0
XILIO THERAPEUTICS INC COM 98422T100 1,314 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 6,052 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 396 217,391 SH   DFND 1,2,3,4,5,6 217,391 0 0
ZYMEWORKS INC COM 98985W102 2,385 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0