The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 2,763 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
AC IMMUNE SA SHS H00263105 7,088 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 5,750 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
ACCELERON PHARMA INC COM 00434H108 45,728 1,050,000 SH   DFND 1,2,3,4,5,6 1,050,000 0 0
ACCELERON PHARMA INC COM 00434H108 8,710 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
ADURO BIOTECH INC COM 00739L101 2,640 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 2,649 1,558,400 SH   DFND 1,2,3,4,5,6 1,558,400 0 0
AGENUS INC COM NEW 00847G705 6,545 2,750,000 SH   DFND 1,2,3,4,5,6 2,750,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 18,444 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 9,222 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 2,627 475,000 SH   DFND 1,2,3,4,5,6 475,000 0 0
ALBIREO PHARMA INC COM 01345P106 12,265 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 2,050 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 56,473 412,000 SH   DFND 1,2,3,4,5,6 412,000 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 10,772 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 36,455 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 21,873 300,000 SH Call DFND 1,2,3,4,5,6 300,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 9,633 300,000 SH Call DFND 1,2,3,4,5,6 300,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 28,740 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 4,790 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
ANAPTYSBIO INC COM 032724106 9,569 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 3,231 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
ARGENX SE SPONSORED ADR 04016X101 25,939 270,000 SH   DFND 1,2,3,4,5,6 270,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 35,625 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 34,740 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 12,792 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
AUTOLUS THERAPEUTICS PLC SPONSORED ADS 05280R100 15,599 475,000 SH   DFND 1,2,3,4,5,6 475,000 0 0
AVROBIO INC COM 05455M100 1,665 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
BANK AMER CORP COM 060505104 110,880 4,500,000 SH Call DFND 1,2,3,4,5,6 4,500,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 84,156 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 28,052 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 17,030 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
BLUEBIRD BIO INC COM 09609G100 17,360 175,000 SH   DFND 1,2,3,4,5,6 175,000 0 0
BLUEBIRD BIO INC COM 09609G100 9,920 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 32,346 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 28,589 550,000 SH Call DFND 1,2,3,4,5,6 550,000 0 0
CELGENE CORP COM 151020104 64,090 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
CHIMERIX INC COM 16934W106 2,570 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 9,996 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 3,592 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 5,998 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 4,143 145,000 SH   DFND 1,2,3,4,5,6 145,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 3,935 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 2,265 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 10,330 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 5,612 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
FATE THERAPEUTICS INC COM 31189P102 27,585 2,150,000 SH   DFND 1,2,3,4,5,6 2,150,000 0 0
FIBROGEN INC COM 31572Q808 13,884 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
FIBROGEN INC COM 31572Q808 6,942 150,000 SH Call DFND 1,2,3,4,5,6 150,000 0 0
FREEPORT-MCMORAN INC CL B 35671D857 20,620 2,000,000 SH Call DFND 1,2,3,4,5,6 2,000,000 0 0
GENERAL MTRS CO COM 37045V100 117,075 3,500,000 SH Call DFND 1,2,3,4,5,6 3,500,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 41,763 250,000 SH Call DFND 1,2,3,4,5,6 250,000 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 3,090 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
HOMOLOGY MEDICINES INC COM 438083107 2,236 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
INFLARX NV COM N44821101 18,185 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 4,425 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,145 110,532 SH   DFND 1,2,3,4 110,532 0 0
KRYSTAL BIOTECH INC COM 501147102 5,715 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 23,348 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 376,652 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 7,890 70,000 SH   DFND 1,2,3,4,5,6 70,000 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,140 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,435 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MEDICINES CO COM 584688105 7,656 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
MEDICINES CO COM 584688105 11,484 600,000 SH Call DFND 1,2,3,4,5,6 600,000 0 0
MELCO RESORT ENTERTAINMENT L ADR 585464100 8,810 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MERUS N V COM N5749R100 2,886 206,125 SH   DFND 1,2,3,4,5,6 206,125 0 0
MICRON TECHNOLOGY INC COM 595112103 12,692 400,000 SH Call DFND 1,2,3,4,5,6 400,000 0 0
MIRAGEN THERAPEUTICS INC COM 60463E103 1,515 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MODERNA INC COM 60770K107 9,926 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
MODERNA, INC. COM 60770K107 70,338 4,606,298 SH   DFND 1,2,3,4 4,606,298 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 2,208 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
MORGAN STANLEY COM NEW 617446448 59,475 1,500,000 SH Call DFND 1,2,3,4,5,6 1,500,000 0 0
NEKTAR THERAPEUTICS COM 640268108 26,296 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
NEKTAR THERAPEUTICS COM 640268108 6,574 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
NIO INC SPONSORED ADS 62914V106 35,672 5,600,000 SH   DFND 1,2,3,4,5,6 5,600,000 0 0
NIO INC SPONSORED ADS 62914V106 6,370 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
NOVELION THERAPEUTICS INC COM NEW 67001K202 215 256,400 SH   DFND 1,2,3,4,5,6 256,400 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 22,092 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
REGENXBIO INC COM 75901B107 7,132 170,000 SH   DFND 1,2,3,4,5,6 170,000 0 0
REPLIMUNE GROUP INC COM 76029N106 4,500 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
RESTORBIO INC COM 76133L103 3,448 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 5,928 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 8,442 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
RUBIUS THERAPEUTICS, INC. COM 78116T103 38,331 2,383,791 SH   DFND 1,2,3,4 2,383,791 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,579 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 4,592 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 8,040 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 44,701 1,946,040 SH   DFND 1,2,3,4 1,946,040 0 0
SELECTA BIOSCIENCES INC COM 816212104 1,596 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 13,400 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 3,690 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,800 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
TG THERAPEUTICS INC COM 88322Q108 1,640 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
TRANSLATE BIO INC COM 89374L104 4,500 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
TRICIDA INC COM 89610F101 2,948 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 257 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 3,464 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
VALE S A ADR 91912E105 6,595 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
VICI PPTYS INC COM 925652109 7,512 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 571,245 14,818,300 SH   DFND 1,2,3,4 14,818,300 0 0
WELLS FARGO CO NEW COM 949746101 69,120 1,500,000 SH Call DFND 1,2,3,4,5,6 1,500,000 0 0
WYNN RESORTS LTD COM 983134107 9,891 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
XENCOR INC COM 98401F105 18,080 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
Y MABS THERAPEUTICS INC COM 984241109 1,017 50,000 SH   DFND 1,2,3,4,5,6 50,000 0 0
ZAFGEN INC COM 98885E103 3,465 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 3,158 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
ZOGENIX INC COM NEW 98978L204 7,292 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0