X0306 4 2022-08-01 0 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001218180 Artal International S.C.A. VALLEY PARK, 44, RUE DE LA VALLEE LUXEMBOURG N4 L-2661 LUXEMBOURG 1 0 1 0 0001841311 Wittouck Amaury VALLEY PARK, 44, RUE DE LA VALLEE LUXEMBOURG N4 L-2661 LUXEMBOURG 1 0 1 0 0001522131 Artal International Management S.A. VALLEY PARK, 44, RUE DE LA VALLEE LUXEMBOURG N4 L-2661 LUXEMBOURG 1 0 1 0 0001053906 Artal Group S.A. VALLEY PARK, 44, RUE DE LA VALLEE LUXEMBOURG N4 L-2661 LUXEMBOURG 1 0 1 0 0001283968 Westend S.A. VALLEY PARK, 44, RUE DE LA VALLEE LUXEMBOURG N4 L-2661 LUXEMBOURG 1 0 1 0 0001460840 Stichting Administratiekantoor Westend CLAUDE DEBUSSYLAAN 46 AMSTERDAM P7 1082 MD NETHERLANDS 1 0 1 0 0001340097 Invus Public Equities, L.P. 750 LEXINGTON AVENUE, 30TH FLOOR NEW YORK NY 10022 1 0 1 0 0001404570 Invus, L.P. 750 LEXINGTON AVENUE, 30TH FLOOR NEW YORK NY 10022 1 0 1 0 0001340096 Invus Public Equities Advisors, LLC 750 LEXINGTON AVENUE, 30TH FLOOR NEW YORK NY 10022 1 0 1 0 0001404553 Invus Advisors, L.L.C. 750 LEXINGTON AVENUE, 30TH FLOOR NEW YORK NY 10022 1 0 1 0 Common Stock 2022-08-01 4 P 0 16173800 2.50 A 48433261 I See Footnotes Common Stock 3516214 I See Footnotes Common Stock 35402689 I See Footnotes On July 27, 2022, Artal International S.C.A. entered into a purchase agreement with the Issuer pursuant to which Artal International S.C.A. agreed to purchase 16,173,800 shares of common stock, $0.001 par value per share (the "Issuer Common Stock"), of the Issuer at a price of $2.50 per share. The purchase closed on August 1, 2022. These securities are directly held by Artal International S.C.A. These securities are directly held by Invus Public Equities, L.P. These securities are directly held by Invus, L.P. Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. Artal International S.C.A. is the managing member of Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A. The parent company of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting. Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose. Invus US Partners LLC (formerly known as Invus Partners, LLC) directly holds 5,303,814 shares of Issuer Common Stock, which securities are being reported on a separately filed Form 4. For purposes of Section 16 of the Exchange Act, the Reporting Persons may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P. See Signatures Included in Exhibit 99.1 2022-08-01