Note 12 - Stock-based Compensation Stock - Stock Option Activity (Details) - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Balance, number of shares (in shares)		349,374
Balance, weighted average exercise price (in dollars per share)		$ 51.15
Balance, weighted average remaining contractual term (Year)	7 years 7 months 6 days	8 years 1 month 6 days
Balance, aggregate intrinsic value	$ 0	$ 358,340
Granted, number of shares (in shares)	310,996
Granted, weighted average exercise price (in dollars per share)	$ 11.79
Expired, number of shares (in shares)	(23,568)
Expired, weighted average exercise price (in dollars per share)	$ 395.1
Outstanding, shares (in shares)	636,802
Outstanding, weighted average exercise price per share (in dollars per share)	$ 19.38
Exercisable, shares (in shares)	316,560
Exercisable, weighted average exercise price per share (in dollars per share)	$ 28.62
Exercisable, weighted average remaining contractual term (Year)	6 years 6 months
Exercisable, aggregate intrinsic value	$ 0