Note 13 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2024

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	2024			2023
Rate reconciliation:
Federal tax benefit at statutory rate		21.0	%		21.0	%
State tax, net of federal benefit		4.4	%		6.3	%
Change in convertible debt		—	%		52.8	%
Research and development credits		3.2	%		17.1	%
Change in valuation allowance		(27.3	)%		(95.9	)%
Share-based compensation		(1.1	)%		(1.0	)%
Other		(0.2	)%		(0.3	)%
Total provision		0.0	%		0.0	%

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	2024			2023
Deferred tax assets:
Net operating loss	$	10,417,666		$	10,495,881
Research and development credits		1,228,255			708,443
Capitalized research expenditures		6,392,545			2,271,853
Stock-based compensation		698,886			567,473
Charitable contributions		1,321			—
Intangibles		193,106			223,548
Gross deferred tax assets		18,931,779			14,267,198
Less valuation allowance		(18,557,844	)		(14,100,543	)
Total deferred tax assets		373,935			166,655
Deferred tax liabilities:
Prepaids	$	(373,935	)	$	(166,655	)
Gross deferred tax liabilities		(373,935	)		(166,655	)
Deferred tax assets, net	$	—		$	—