Note 8- Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2023

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

	Three Months Ended March 31,
	2023		2022
Research and development	$	12,011	$	58,892
General and administrative		109,360		219,239
Total stock-based compensation expense	$	121,371	$	278,131

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

	Number of Options			Weighted average exercise price per share		Weighted average remaining contractual life (in years)		Aggregate intrinsic value
Balance at January 1, 2023		140,040		$	126.75
Granted		—			—
Cancelled		(35,993	)		20.13
Outstanding at March 31, 2023		104,047		$	163.64		7.99	$	—
Exercisable at March 31, 2023		78,533		$	211.21		7.75	$	—
Vested and expected to vest at March 31, 2023		104,047		$	163.64		7.99	$	—

Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]

	Number of Units			Weighted average grant date fair value
Balance at January 1, 2023		3,652		$	36.49
Vested (1)		(742	)		33.72
Outstanding at March 31, 2023		2,910		$	38.28