Note 8 - Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($)	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021
Research and development	$ 928,052	$ 897,260
Research and Development Expense [Member]
Research and development	215,904	154,041
General and Administrative Expense [Member]
Research and development	$ 712,148	$ 743,219

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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