Note 8 - Income Taxes - Reconciliation of Income Tax Rate (Details)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Federal tax benefit at statutory rate	(21.00%)	(21.00%)
State tax, net of Federal benefit	(4.70%)	(4.70%)
Orphan drug credit	(0.40%)	(2.90%)
Change in valuation allowance	24.30%	18.10%
Total provision	(1.80%)	(10.50%)