Note 8 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)	Dec. 31, 2021	Dec. 31, 2020
Net operating loss carryforwards	$ 6,033,726	$ 3,864,189
Stock option compensation	1,641,354	1,571,227
Orphan Drug credits	647,937	541,384
Lease liability	0	38,394
Capitalized start-up costs and other	12,403,925	10,709,631
Valuation allowance	(20,726,942)	(14,906,646)
Deferred tax assets	0	1,818,179
Intangible assets	0	(2,223,678)
Right of use asset	0	(38,394)
Deferred tax liabilities	0	(2,262,072)
Net deferred tax liability	$ 0	$ (443,893)