<SEC-DOCUMENT>0001437749-18-015228-index.html : 20180810
<SEC-HEADER>0001437749-18-015228.hdr.sgml : 20180810
<ACCEPTANCE-DATETIME>20180810162210
ACCESSION NUMBER:		0001437749-18-015228
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		4
REFERENCES 429:			333-206408
REFERENCES 429:			333-218060
FILED AS OF DATE:		20180810
DATE AS OF CHANGE:		20180810
EFFECTIVENESS DATE:		20180810

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
		CENTRAL INDEX KEY:			0001053691
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				300645032
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-226782
		FILM NUMBER:		181009114

	BUSINESS ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902
		BUSINESS PHONE:		(434) 220-0718

	MAIL ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RestorGenex Corp
		DATE OF NAME CHANGE:	20140307

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Stratus Media Group, Inc
		DATE OF NAME CHANGE:	20080722

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
		DATE OF NAME CHANGE:	20080228
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>dffn20180809_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
Document 1 - file: dffn20180809_s8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ex_121235.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: ex_121235.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>ex_121236.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 3 - file: ex_121236.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>logo.jpg
<TEXT>
Document 4 - file: logo.jpg

</DOCUMENT>
</SEC-DOCUMENT>