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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies (Tables)
6 Months Ended
Jun. 30, 2018
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended June 30,
   
Six Months Ended June 30,
 
   
2018
   
2017
   
2018
   
2017
 
Basic net (loss) income per common share calculation:
                               
Net (loss) income
  $
(2,765,181
)
  $
20,387,741
    $
(6,079,142
)
  $
(8,251,037
)
Accretion of Series A cumulative preferred dividends
   
     
(487,460
)
   
(85,993
)
   
(546,305
)
Undistributed earnings allocated to participating securities
   
     
(10,416,153
)
   
 
     
 
 
Deemed dividend related to the make-whole provision for the conversion of Series A preferred stock into common
   
     
     
(8,167,895
)
   
 
Net (loss) income attributable to common
   
(2,765,181
)
   
9,484,128
     
(14,333,030
)
   
(8,797,342
)
                                 
Weighted average common shares outstanding, basic
   
50,546,021
     
10,828,063
     
46,357,478
     
10,582,521
 
Net (loss) income per share of common, basic
  $
(0.05
)
  $
0.88
    $
(0.31
)
  $
(0.83
)
                                 
Diluted net income (loss) per common share calculation:
                               
Net income (loss) attributable to common
   
(2,765,181
)
   
9,484,128
     
(14,333,030
)
   
(8,797,342
)
Add change in fair value of warrant liability
   
     
(23,387,850
)
   
     
(10,468,176
)
Diluted net loss
   
(2,765,181
)
   
(13,903,722
)
   
(14,333,030
)
   
(19,265,518
)
Weighted average common shares outstanding, basic
   
50,546,021
     
10,828,063
     
46,357,478
     
10,582,521
 
Add shares from dilutive warrants
   
     
3,044,569
     
     
1,756,865
 
Common stock equivalents
   
50,546,021
     
13,872,632
     
46,357,478
     
12,339,386
 
Diluted net loss per share of common
  $
(0.05
)
  $
(1.00
)
  $
(0.31
)
  $
(1.56
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
June 30,
 
   
2018
   
2017
 
Convertible debt
   
     
774,886
 
Convertible preferred stock
   
     
10,449,338
 
Common stock warrants
   
31,312,512
     
457,721
 
Stock options
   
3,213,797
     
2,525,989
 
Unvested restricted stock awards
   
     
6,132
 
     
34,526,309
     
14,214,066