Note 14 - Income Taxes - Reconciliation of Income Tax Rate (Details)	12 Months Ended
	Dec. 31, 2016
Federal tax benefit at statutory rate	(34.00%)
State tax, net of Federal benefit	(2.30%)
Litigation settlement charge	4.60%
Acquisition costs	2.80%
Orphan drug credit	(4.40%)
Change in valuation allowance	27.20%
Stock compensation	4.20%
Other	(0.10%)
Total provision	(2.00%)