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Note 12 - Stock-based Compensation - Stock Option Activity (Details) - USD ($)
12 Months Ended
Dec. 31, 2016
Jan. 08, 2016
Balance at January 1, 2016 (in shares) 1,495,615  
Balance at January 1, 2016 (in dollars per share) $ 3.92  
Cancelled (in shares) (48,190)  
Cancelled (in dollars per share) $ 61.30  
Granted (in shares) 458,828  
Granted (in dollars per share) $ 6.25  
Options outstanding (in shares) 2,207,409  
Options outstanding, weighted-average per share exercise price (in dollars per share) $ 8.09  
Options outstanding, weighted-average remaining contractual life (Year) 7 years 292 days  
Options outstanding, weighted-average remaining contractual life [1] $ 94,599  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number 1,446,121 301,156
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price $ 9.36 $ 40.13
Exercisable at December 31, 2016 (Year) 7 years  
Exercisable at December 31, 2016 [1] $ 94,599  
Vested and expected to vest at December 31, 2016 (in shares) 2,203,011  
Vested and expected to vest at December 31, 2016 (in dollars per share) $ 8.09  
Vested and expected to vest at December 31, 2016 (Year) 7 years 292 days  
Vested and expected to vest at December 31, 2016 [1] $ 94,599  
Diffusion LLC [Member]    
RestorGenex options outstanding (in shares) 301,156  
RestorGenex options outstanding (in dollars per share) $ 40.13  
[1] The difference, if positive, between the stock option's exercise price and the closing price of the Company's common stock at December 31, 2016.