Note 6 - Goodwill and Intangible Assets - Intangible Assets (Details)	12 Months Ended
Dec. 31, 2016 USD ($)
RES-529 [Member]
Intangible assets, gross carrying amount	$ 8,639,000
Intangible assets, net (excluding goodwill)	8,639,000
RES-440 [Member]
Intangible assets, gross carrying amount	961,000
Intangible assets, net (excluding goodwill)	0
Intangible assets, impairment	(961,000)
In Process Research and Development Costs (IPR&D) [Member]
Intangible assets, gross carrying amount	9,600,000
Intangible assets, net (excluding goodwill)	8,639,000
Intangible assets, impairment	$ (961,000)

The amount of impairment loss recognized in the period resulting from the write-down of the carrying amount of an intangible asset (excluding goodwill) to fair value.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 350
-SubTopic 30
-Section 50
-Paragraph 3
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16373-109275

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585

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Amount before accumulated amortization of intangible assets, excluding goodwill.

+ References

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Sum of the carrying amounts of all intangible assets, excluding goodwill, as of the balance sheet date, net of accumulated amortization and impairment charges.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 350
-SubTopic 30
-Section 45
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6388964&loc=d3e16212-109274

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 350
-SubTopic 30
-Section 50
-Paragraph 2
-Subparagraph ((a)(1),(b))
-URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275

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