Note 14 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Notes Tables

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

Deferred tax assets	December 31, 2016
Net operating loss carryforwards	$	7,547,296
Stock option compensation		2,720,186
Orphan Drug credits		1,218,069
Capitalized start-up costs and other		4,690,843
Valuation allowance		(16,176,394	)
Net deferred tax asset	$	—
Deferred tax liabilities
Intangible assets		(3,279,363	)
Net deferred tax liability	$	(3,279,363	)

Summary of Valuation Allowance [Table Text Block]

Valuation allowance at beginning of year	$	—
Changes recorded to income tax provision		5,017,047
Changes recorded in purchase accounting		11,159,347
Valuation allowance at end of year	$	16,176,394

Summary of Operating Loss Carryforwards [Table Text Block]

Combined NOL Carryforwards:	December 31, 2016
Federal	$	19,842,612
State	$	20,222,492

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

Rate reconciliation:	December 31, 2016
Federal tax benefit at statutory rate		(34.0	) %
State tax, net of Federal benefit		(2.3	)
Litigation settlement charge		4.6
Acquisition costs		2.8
Orphan drug credit		(4.4	)
Change in valuation allowance		27.2
Stock compensation		4.2
Other		(0.1	)
Total provision		(2.0	) %