Note 12 - Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2016

Notes Tables

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

	Year ended December 31 ,
	2016		2015
Research and development	$	674,643	$	309,579
General and administrative		716,425		284,596
Total stock-based compensation expense	$	1,391,068	$	594,175

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

	Number of Options			Weighted average exercise price per share		Weighted average remaining contractual life (in years)		Aggregate Intrinsic Value (A)
Balance at January 1, 2016		1,495,615		$	3.92
RestorGenex options outstanding		301,156			40.13
Cancelled		(48,190	)		61.30
Granted		458,828			6.25
Outstanding at December 31, 2016		2,207,409		$	8.09		7.8		$94,599
Exercisable at December 31, 2016		1,446,121		$	9.36		7.0		$94,599
Vested and expected to vest at December 31, 2016		2,203,011		$	8.09		7.8		$94,599

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	2016			2015
Expected term (in years)	5.76	-	7.48		5.76
Risk-free interest rate	1.2%	-	2.0%	2.1%	-	2.3%
Expected volatility	106.8%	-	125.5%	125.6%	-	125.8%
Dividend yield		0%			0%