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Note 10 - Income Taxes (Details Textual) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
In Process Research and Development Costs (IPR&D) [Member]        
Deferred Tax Liabilities, Net $ 3,644,159   $ 3,644,159  
Impairment of Intangible Assets (Excluding Goodwill)     961,000  
RES-440 [Member] | Research and Development Expense [Member]        
Impairment of Intangible Assets (Excluding Goodwill)     951,000  
RES-440 [Member]        
Impairment of Intangible Assets (Excluding Goodwill)     961,000  
Abandonmnet of In-Process Research and Development Intangible Asset [Member]        
Income Tax Expense (Benefit)     364,796  
Income Tax Expense (Benefit) $ (364,796) $ (364,796)