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Note 10 - Stock-Based Compensation (Tables)
6 Months Ended
Jun. 30, 2015
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
 
 
Three Months Ended
June 30
,
 
 
Six
Months Ended
June 30
,
 
 
 
2015
 
 
2014
 
 
2015
 
 
2014
 
Research and development
  $ 152,645     $ 32,825     $ 384,170     $ 32,825  
General and administrative
    374,544       108,490       748,446       258,375  
Total stock-based compensation expense
  $ 527,189     $ 141,315     $ 1,132,616     $ 291,200