X0306 4 2022-08-01 0001049502 MKS INSTRUMENTS INC MKSI 0001256715 COLELLA GERARD G C/O MKS INSTRUMENTS, INC. 2 TECH DRIVE, SUITE 201 ANDOVER MA 01810 1 Common Stock 2022-08-01 4 P 0 1000 117.51 A 99017 I By The Gerald G. Colella Living Trust Common Stock 1746.684 D Common Stock 0 I By The Gerald G. Colella 2018 Grantor Trust /s/ M. Kathryn Rickards, attorney-in-fact 2022-08-02