Equity Incentive Plans and Warrants (Details Textual) (USD $)	1 Months Ended					12 Months Ended								12 Months Ended		1 Months Ended		1 Months Ended		1 Months Ended		1 Months Ended	12 Months Ended	1 Months Ended	12 Months Ended	1 Months Ended		12 Months Ended
	Oct. 31, 2011	Oct. 31, 2009	Feb. 29, 2008	Jun. 20, 2007	Feb. 28, 2003	Dec. 31, 2012	Dec. 31, 2011 Executives	Dec. 31, 2010	Oct. 30, 2011	Dec. 31, 2009	Dec. 30, 2009	Oct. 09, 2009	Feb. 28, 2008	Dec. 31, 2012 Athyrium Credit Agreement [Member]	Dec. 31, 2012 Stock Options [Member]	Jun. 20, 2007 Celunol Equity Incentive Plan [Member]	Dec. 31, 2012 Celunol Equity Incentive Plan [Member]	Apr. 30, 2010 2010 Equity Incentive Plan [Member]	Dec. 31, 2012 2010 Equity Incentive Plan [Member]	Mar. 31, 2007 2007 Equity Incentive Plan [Member]	Dec. 31, 2012 2007 Equity Incentive Plan [Member]	Mar. 31, 2005 2005 Non-Employee Directors Equity Incentive Plan [Member]	Dec. 31, 2012 2005 Non-Employee Directors Equity Incentive Plan [Member]	Aug. 31, 1997 1997 Equity Incentive Plan [Member]	Dec. 31, 2012 1997 Equity Incentive Plan [Member]	Aug. 31, 1997 1997 Equity Incentive Plan [Member] Incentive [Member]	Aug. 31, 1997 1997 Equity Incentive Plan [Member] Stock Options [Member]	Dec. 31, 2012 Maximum [Member]	Dec. 31, 2012 Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Fair value of restricted awards amortized to share based compensation expense over the vesting period						6 years	6 years	6 years
Warrants issued to purchase common stock			700,000
Option granted over Vest period															4 years	4 years		4 years		4 years		3 years		4 years				4 years	2 years
Option granted Over expire period																10 years		10 years		10 years		10 years		10 years
Common stock are reserved																	3,998		1,827,254		723,884	50,000	80,482
Options to purchase of Shares outstanding						1,993,000	1,819,000	1,209,000		787,000							3,998		1,359,840		553,555		75,888		425
Maximum Annual Increase																							20,833
Percentage of exercise price																										100.00%	85.00%
Aggregate number of shares awarded						551,000	884,000	784,000																	1,183,000
Exercise price of Warrants		0.40		22.44	264	208.73			2.64		61.92	7.59	53.28	2.49
Period of warrant		5 years			10 years									7 years
Equity Incentive Plans and Warrants (Textual) [Abstract]
Share-based compensation expense						$ 1,100,000	$ 1,300,000	$ 1,100,000
Total unrecognized compensation expense						1,824,000
Outstanding unvested options is expected to be recognized over a weighted average period						1 year 8 months 12 days
Purchase price of warrant		900,000			100,000	2,900,000			200,000		1,100,000
Share expiration date			August 2013	December 2016
Increase in number of shares issuable upon exercise of the warrants						1,200,000
Price of shares issuable upon exercise of warrants						$ 29.72
Warrant date	The warrants have an exercise period commencing on April 19, 2012 and are exercisable for five years ending October 19, 2016.		The warrants are exercisable on three dates staggered in six month intervals beginning on October 1, 2013
Business acquisition cost of acquired entity warrants issued and issuable				28,000
Exercise price of Warrants						$ 3.76
Expected Life						6 years	6 years	6 years
Exercise price per share of the warrant						$ 2.86	$ 0.72	$ 1.37
Common stock, shares issued						12,783,000	12,611,000
Executives separated from the company							2
Sale of common stock		2,200,000				2,200,000
Option vesting period for separated executives							24 months
Forfeiture rate						5.00%	5.00%	10.00%
Weighted average estimated fair value of options granted						$ 2.42	$ 1.68	$ 2.62
Options to purchase						715,000	600,000
Aggregate intrinsic value of options exercisable						81,000	8,000
Total intrinsic value of options exercised						87,000	8,000	27,000
Shares available for grant						1,000,000
Price based anti-dilution adjustments						$ 2.12
Floor exercise price per share						$ 2.12
Antidilutive securities related to warrant and stock options						2,600,000
Reclassified to stockholders' equity.						$ 700,000