Equity Incentive Plans and Warrants (Details 5) In Thousands, unless otherwise specified	Dec. 31, 2012	Oct. 30, 2011	Dec. 30, 2009	Oct. 31, 2009	Oct. 09, 2009	Feb. 28, 2008	Jun. 20, 2007	Feb. 28, 2003
Class of Warrant or Right [Line Items]
Shares	6,518
Exercise Price	208.73	2.64	61.92	0.40	7.59	53.28	22.44	264.00
Athyrium Opportunities Fund [Member]
Class of Warrant or Right [Line Items]
Shares	2,936
Exercise Price	2.49
Issue Date	December 2012
Expiration Date	December 2019
Comerica Bank [Member]
Class of Warrant or Right [Line Items]
Shares	246
Exercise Price	2.64
Issue Date	October 2011
Expiration Date	October 2016
Various (Public offering) [Member]
Class of Warrant or Right [Line Items]
Shares	900
Exercise Price	7.59
Issue Date	October 2009
Expiration Date	October 2014
Various (Celunol) [Member]
Class of Warrant or Right [Line Items]
Shares	28
Exercise Price	22.44
Issue Date	various
Expiration Date	December 2016
Various (2008 Notes) [Member]
Class of Warrant or Right [Line Items]
Shares	1,193
Exercise Price	29.72
Issue Date	February 2008
Expiration Date	August 2013
Convertible hedge-Upper Call (2008 Notes) [Member]
Class of Warrant or Right [Line Items]
Shares	1,107
Exercise Price	61.92
Issue Date	February 2008
Expiration Date	October 2014
Syngenta [Member]
Class of Warrant or Right [Line Items]
Shares	108
Exercise Price	208.73
Issue Date	February 2003
Expiration Date	February 2018