Equity Incentive Plans and Warrants (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Share-based compensation expense by category
Share based compensation expense, total	$ 1,068	$ 1,437	$ 1,320
Continuing Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	1,068	1,347	1,091
Discontinued Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	0	90	229
Cost of product and contract manufacturing revenue [Member] | Continuing Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	76	0	0
Research and development [Member] | Continuing Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	191	280	0
Research and development [Member] | Discontinued Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	0	0	16
Selling, general and administrative [Member] | Continuing Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	801	484	1,091
Selling, general and administrative [Member] | Discontinued Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	0	90	213
Restructuring charges [Member] | Continuing Operations [Member]
Share-based compensation expense by category
Share based compensation expense, total	$ 0	$ 583	$ 0