Commitment and Contingencies (Details Textual) (USD $)	12 Months Ended									12 Months Ended	1 Months Ended	12 Months Ended		12 Months Ended		12 Months Ended
	Dec. 31, 2012 Months	Dec. 31, 2011	Dec. 31, 2010	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012	Mar. 02, 2012	Sep. 30, 2011	Jun. 30, 2011	Dec. 31, 2012 Revised Expiration Date [Member]	Dec. 31, 2012 San Diego [Member]	Dec. 31, 2012 San Diego [Member]	Jun. 24, 2011 San Diego [Member] sqft	Dec. 31, 2012 Cambridge Lease [Member] sqft	Dec. 31, 2012 Maximum [Member]	Dec. 31, 2012 Maximum [Member] San Diego [Member]	Dec. 31, 2012 Minimum [Member] San Diego [Member]	Dec. 31, 2012 Escrow [Member]	Sep. 02, 2010 Escrow [Member]	Dec. 31, 2012 Escrow-Remaining [Member]	Dec. 31, 2012 Escrow Disbursed [Member]	Dec. 31, 2012 Building Improvements [Member] San Diego [Member]
Commitment and Contingencies (Textual) [Abstract]
Rent expense											$ 192,000	$ 200,000		$ 700,000
Cash rental payments												1,300,000
Interest expense												1,000,000
Lease financing obligation current portion	127,000	0	0									100,000
Addition to the tenant allowance	1,500,000											1,500,000
Tenant allowance option exercised interest rate	9.00%
New office and laboratory space leased asset													59,199
Lease agreement period												126 months
Minimum rental commitment	100,000
Percentage of increase in lease rental payment												3.00%
Free rent term beginning period																	7 months
Free rent term ending period																16 months
Percentage of tenant improvement allowance and an equipment allowance interest rate												9.00%
Options to extend term of lease												5 years
Prior exercised written notice to extend term of lease												12 months
Lease financing obligation, long term liabilities		7,135,000		21,352,000	19,962,000	11,357,000		968,000	930,000
Future minimum lease financing obligation											27,300,000	27,300,000
Lease financing obligation balance at the end											13,800,000	13,800,000
Company leases office space														21,000
Building and Improvements costs																						23,300,000
Lease financing obligation											22,000,000	22,000,000
Maturity date	Dec. 31, 2012									Dec. 31, 2022
Reduced restricted cash	0	3,200,000		1,600,000	3,200,000	3,200,000		0	0
Revolving credit facility borrowings	1,600,000
Cancellation of commitment, period	30
Period of minimum commitment	2 years 7 months 6 days
Incurred cost for property and equipment	23,200,000
Minimum commitment	49,500,000
Funds Received	700,000
Purchase Price																		2,500,000	5,000,000
Maximum amount of indemnification liability	2,000,000														10,000,000
Resolution of indemnification claim amount																				2,500,000	2,500,000
Restricted cash	2,500,000	5,000,000		2,500,000	2,500,000	2,500,000		5,000,000	5,000,000									2,500,000
Proceeds from sale of LC business			$ 96,000,000
Asset purchase agreement							18 months