Discontinued Operations (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended								6 Months Ended	9 Months Ended		12 Months Ended
	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012	Dec. 31, 2011	Sep. 30, 2011	Jun. 30, 2011	Mar. 31, 2011	Jun. 30, 2012	Sep. 30, 2012	Sep. 30, 2011	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Results of operations from discontinued operations
Collaborative		$ 697	$ 969	$ 5,508	$ 578	$ 3,674			$ 6,477	$ 7,174	$ 4,694	$ 8,269	$ 5,272	$ 1,722
Total revenue	13,983	10,262	15,697	17,229	14,321	18,416	15,134	13,396	32,926	43,188	46,946	57,171	61,267	52,073
Research and development		3,806	3,833	3,161	3,393	2,725			7,041	10,800	7,645	15,060	11,038	6,198
Selling, general and administrative		4,523	4,304	5,908	5,208	4,617			10,212	14,735	13,783	19,567	18,991	27,662
Loss from discontinued operations												(56)	(112)	(37,340)
Gain on sale of LC Business												0	0	55,904
Income tax provision												0	0	(9,748)
Net loss from discontinued operations		(23)	(11)	(15)	(149)	(24)			(26)	(49)	37	(56)	(112)	8,816
Revenue From Discontinued Operations [Member]
Results of operations from discontinued operations
Grant												0	0	7,487
Collaborative												0	0	185
Total revenue												0	0	7,672
Discontinued Operations of Operating Expenses [Member]
Results of operations from discontinued operations
Research and development												0	(13)	38,060
Selling, general and administrative												56	125	6,952
Total operating expenses												$ 56	$ 112	$ 45,012