Equity Incentive Plans and Warrants (Tables)

12 Months Ended

Dec. 31, 2012

Equity Incentive Plans and Warrants [Abstract]

Share-based compensation expense by category

	Years Ended December 31,
	2012		2011		2010
Continuing Operations:
Cost of product and contract manufacturing revenue	$	76	$	0	$	0
Research and development		191		280		0
Selling, general and administrative		801		484		1,091
Restructuring charges		0		583		0
	$	1,068	$	1,347	$	1,091
Discontinued Operations:
Research and development	$	0	$	0	$	16
Selling, general and administrative		0		90		213
	$	0	$	90	$	229
	$	1,068	$	1,437	$	1,320

Fair value of stock options awards

	December 31,
	2012	2011	2010
Risk-free interest rate	0.97% to 1.67%	1.4% to 3.0%	1.9% to 3.2%
Dividend Yield	0%	0%	0%
Volatility	66.91%	66.91% to 135%	135%
Expected Life	6 years	6 years	6 years

Share-based compensation expense outstanding unvested options to be recognized

Fiscal Year 2013	$	1,013
Fiscal Year 2014		512
Fiscal Year 2015		216
Fiscal Year 2016		61
Thereafter		22
	$	1,824

Summary of Company's stock option activity

	Shares			Weighted Average Exercise Price per Share		Weighted Average Remaining Contractual Term (in Years)		Aggregate Intrinsic Value
Outstanding at January 1, 2010		787		$	15.75
Granted		784		$	2.90
Exercised		(11	)	$	1.37
Cancelled		(351	)	$	22.62
Outstanding at December 31, 2010		1,209		$	5.56
Granted		884		$	2.20
Exercised		(2	)	$	0.72
Cancelled		(272	)	$	11.30
Outstanding at December 31, 2011		1,819		$	3.07
Granted		551		$	4.08
Exercised		(174	)	$	2.86
Cancelled		(203	)	$	3.12
Outstanding at December 31, 2012		1,993		$	3.36		8.4	$	257
Exercisable at December 31, 2012		715		$	3.76		7.7	$	81

Company's non-restricted and restricted share awards

	Shares			Weighted Average Fair  Value
Non-vested awards outstanding at January 1, 2010		8		$	15.62
Granted		10		$	3.05
Vested		(6	)	$	14.51
Forfeited and cancelled		(2	)	$	14.64
Non-vested awards outstanding at December 31, 2010		10		$	3.67
Granted		0		$	0.00
Vested		(6	)	$	3.87
Forfeited and cancelled		0		$	0.00
Non-vested awards outstanding at December 31, 2011		4		$	3.35
Granted		0		$	0.00
Vested		(4	)	$	3.05
Forfeited and cancelled		0		$	0.00
Non-vested awards outstanding at December 31, 2012		0		$	0

Summary of outstanding warrants

Warrant Holder	Shares		Exercise Price		Issue Date	Expiration Date
Athyrium Opportunities Fund		2,936	$	2.49	December 2012	December 2019
Comerica Bank		246	$	2.64	October 2011	October 2016
Various (Public offering)		900	$	7.59	October 2009	October 2014
Various (Celunol)		28	$	22.44	various	December 2016
Various (2008 Notes)		1,193	$	29.72	February 2008	August 2013
Convertible hedge–Upper Call (2008 Notes)		1,107	$	61.92	February 2008	October 2014
Syngenta		108	$	208.73	February 2003	February 2018
Total		6,518

Company has reserved shares of common stock for future issuance

	Shares
Equity Incentive Plans		2,636
Warrants (including shares issuable under the convertible hedge transaction)		6,518
		9,154