Share-based Compensation (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Share-based compensation expense by category
Share based compensation expense, total	$ 304	$ 188	$ 746	$ 1,058
Cost of product and contract manufacturing revenue [Member]
Share-based compensation expense by category
Share based compensation expense, total	25	0	49	0
Research and development [Member]
Share-based compensation expense by category
Share based compensation expense, total	65	0	116	0
Selling, general and administrative [Member]
Share-based compensation expense by category
Share based compensation expense, total	214	188	581	475
Restructuring charges [Member]
Share-based compensation expense by category
Share based compensation expense, total	$ 0	$ 0	$ 0	$ 583