Stradley Ronon Stevens & Young, LLP   1250 Connecticut Avenue, N.W., Suite 500   Washington, DC 20036   Telephone 202.822.9611   Fax 202.822.0140   www.stradley.com

Jessica D. Burt, Esquire

202.419.8409

jburt@stradley.com

1933 Act Rule 497(e)

1933 Act File No. 333-40455

1940 Act File No. 811-08495

June 28, 2018

VIA EDGAR

Filing Desk

U.S. Securities and Exchange Commission

100 F Street, NE

Washington, DC 20549

Re: Nationwide Mutual Funds (the “Registrant”)

File Nos. 333-40455 and 811-08495

Rule 497(e) filing                                                     

Ladies and Gentlemen:

Enclosed for filing pursuant to Rule 497(e) under the Securities Act of 1933, as amended (the “1933 Act”), are exhibits of certain risk/return summary information in an interactive data format using the eXtensible Business Reporting Language (the “XBRL Exhibits”). The XBRL Exhibits reflect the risk/return summary disclosure that was included in the supplement dated June 14, 2018 to the Registrant’s currently effective prospectus, relating to the Nationwide Diamond Hill Large Cap Concentrated Fund (formerly, Nationwide Large Cap Growth Fund) and Nationwide Growth Fund, each a series of the Registrant, which was filed with the U.S. Securities and Exchange Commission via the EDGAR system on June 14, 2018 (SEC Accession No. 0001680359-18-000269) pursuant to Rule 497(e) under the 1933 Act.

Please direct questions or comments relating to this filing to me at the above-referenced telephone number.

Very truly yours,

/s/ Jessica D. Burt

Jessica D. Burt, Esquire

A Pennsylvania Limited Liability Partnership