<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001746640</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001048695</issuerCik>
            <issuerName>F5, INC.</issuerName>
            <secFileNumber>000-26041</secFileNumber>
            <issuerAddress>
                <ns2:street1> 801 5th Avenue</ns2:street1>
                <ns2:city>Seattle</ns2:city>
                <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                <ns2:zipCode>98104</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>2062725555</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHAD WHALEN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6200</noOfUnitsSold>
            <aggregateMarketValue>2139124.00</aggregateMarketValue>
            <noOfUnitsOutstanding>56419247</noOfUnitsOutstanding>
            <approxSaleDate>05/08/2026</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/01/2025</acquiredDate>
            <natureOfAcquisitionTransaction>RSU/PSU</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6200</amountOfSecuritiesAcquired>
            <paymentDate>02/01/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CHAD WHALEN</name>
                <address>
                    <ns2:street1> 801 5th Avenue</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/04/2026</saleDate>
            <amountOfSecuritiesSold>704</amountOfSecuritiesSold>
            <grossProceeds>232531.62</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CHAD WHALEN</name>
                <address>
                    <ns2:street1> 801 5th Avenue</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/06/2026</saleDate>
            <amountOfSecuritiesSold>688</amountOfSecuritiesSold>
            <grossProceeds>190610.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units and performance stock units during the period of 2/1/2025 through 8/1/2025.
</remarks>
        <noticeSignature>
            <noticeDate>05/08/2026</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/05/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Chad Whalen</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
