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Disaggregates of Total Revenues from External Customers and Collaborative Partners by Geographic Region (Detail) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Revenue from External Customer [Line Items]        
Total revenues $ 391,706 $ 334,148 $ 1,137,998 $ 955,341
United States        
Revenue from External Customer [Line Items]        
Total revenues 174,722 151,012 528,082 425,107
Europe        
Revenue from External Customer [Line Items]        
Total revenues 111,069 121,268 323,940 292,845
Latin America        
Revenue from External Customer [Line Items]        
Total revenues 55,322 9,546 151,955 121,581
Rest of World        
Revenue from External Customer [Line Items]        
Total revenues $ 50,593 $ 52,322 $ 134,021 $ 115,808