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Disaggregates of Total Revenues from External Customers and Collaborative Partners by Geographic Region (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Revenue from External Customer [Line Items]        
Total revenues $ 372,845 $ 317,448 $ 746,292 $ 621,193
United States        
Revenue from External Customer [Line Items]        
Total revenues 162,788 141,611 353,360 274,095
Europe        
Revenue from External Customer [Line Items]        
Total revenues 107,221 87,672 212,871 171,577
Latin America        
Revenue from External Customer [Line Items]        
Total revenues 58,158 66,739 96,633 112,035
Rest of World        
Revenue from External Customer [Line Items]        
Total revenues $ 44,678 $ 21,426 $ 83,428 $ 63,486