PROPERTY, PLANT AND EQUIPMENT

6 Months Ended

Jun. 30, 2018

Property Plant And Equipment [Abstract]

PROPERTY, PLANT AND EQUIPMENT

(8) PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment, net consisted of the following:

	June 30,			December 31,
	2018			2017
Building and improvements	$	674,682		$	663,347
Manufacturing and laboratory equipment		316,331			294,521
Computer hardware and software		152,010			144,268
Leasehold improvements		38,352			42,572
Furniture and equipment		30,833			31,515
Land improvements		5,977			5,331
Land		62,369			62,369
Construction-in-progress		60,582			59,511
		1,341,136			1,303,434
Accumulated depreciation		(440,656	)		(406,734	)
Total property, plant and equipment, net	$	900,480		$	896,700

The construction-in-process balance primarily includes costs related to the Company’s significant in-process projects at its facilities in Marin County, California, and in Shanbally, Ireland.

Depreciation expense for the three and six months ended June 30, 2018 was $20.1 million and $40.1 million, respectively, of which $6.6 million and $10.5 million, respectively, was capitalized into inventory. Depreciation expense for the three and six months ended June 30, 2017 was $17.9 million and $35.4 million, respectively, of which $6.2 million and $11.8 million, respectively, was capitalized into inventory. Capitalized interest related to the Company’s property, plant and equipment purchases for each of the three and six months ended June 30, 2018 and 2017 was insignificant.