INCOME TAXES (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Schedule of Provision for (Benefit from) Income Taxes Based on Loss Before Income Taxes

The provision for (benefit from) income taxes is based on loss before income taxes as follows:

	Years Ended December 31,
	2017			2016			2015
U.S. Source	$	(19,461	)	$	10,696		$	182,215
Non-U.S. Source		(16,414	)		(841,746	)		(336,939	)
Loss before income taxes	$	(35,875	)	$	(831,050	)	$	(154,724	)

Schedule of Components of Provision for (Benefit From) Income Taxes

The U.S. and foreign components of the provision for (benefit from) income taxes are as follows:

	Years Ended December 31,
	2017			2016			2015
Provision for current income tax expense:
Federal	$	29,848		$	22,239		$	84,743
State and local		2,880			1,418			5,323
Foreign		3,975			3,557			3,836
		36,703			27,214			93,902
Provision for (benefit from) deferred income tax    expense:
Federal		12,446			(78,428	)		(17,741	)
State and local		32,336			(6,012	)		(8,770	)
Foreign		(318	)		(143,614	)		(50,316	)
		44,464			(228,054	)		(76,827	)
Provision for (benefit from) income taxes	$	81,167		$	(200,840	)	$	17,075

Schedule of Reconciliation of Statutory Federal Income Tax Rate to Company's Effective Income Tax Rate

The following is a reconciliation of the statutory federal income tax rate to the Company’s effective income tax rate expressed as a percentage of loss before income taxes:

	Years Ended December 31,
	2017			2016			2015
Federal statutory income tax rate		35.0	%		35.0	%		35.0	%
State and local taxes		(20.3	)%		0.4	%		(2.2	)%
Orphan Drug & General Business Credit		93.9	%		7.5	%		34.8	%
Stock compensation expense		19.1	%		4.6	%		(2.8	)%
Changes in the fair value of contingent acquisition consideration payable		(3.1	)%		0.9	%		0.2	%
Subpart F income		(84.1	)%		—	%		(8.4	)%
Foreign tax rate differential		(26.2	)%		(18.6	)%		(46.2	)%
Section 162(m) limitation		(26.5	)%		(5.4	)%		(1.3	)%
Tax Cuts and Jobs Act of 2017		(118.0	)%		—	%		—	%
Other		1.9	%		0.3	%		(1.6	)%
Valuation allowance/deferred benefit		(97.9	)%		(0.5	)%		(18.5	)%
Effective income tax rate		(226.2	)%		24.2	%		(11.0	)%

Schedule of Components of Net Deferred Tax Assets

The significant components of the Company’s net deferred tax assets are as follows:

	December 31,
	2017			2016
Net deferred tax assets:
Net operating loss carryforwards	$	48,374		$	49,787
Tax credit carryforwards		384,381			352,535
Accrued expenses, reserves, and prepaids		54,565			77,904
Intangible assets		17,556			26,751
Stock-based compensation		31,371			47,713
Inventory		13,206			15,581
Impairment		2,609			5,017
Other		2,358			1,519
Valuation allowance		(111,001	)		(73,037	)
Total deferred tax assets		443,419			503,770
Joint venture basis difference		(1,229	)		(1,714	)
Acquired intangibles		(3,332	)		(8,773	)
Convertible notes discount		(10,100	)		(24,394	)
Property, plant and equipment		(29,663	)		(22,103	)
Total deferred tax liabilities		(44,324	)		(56,984	)
Net deferred tax assets	$	399,095		$	446,786

Summary of Expiration of not Utilized Net Operating Loss and Tax Credit Carryforwards

As of December 31, 2017, the Company had the following net operating loss and tax credit carryforwards, which if not utilized, will expire as follows (dollars in thousands):

Type	Amount		Year
Federal net operating loss carryforwards	$	15,554	2028 – 2033
Federal R&D and orphan drug credit carryforwards	$	403,828	2030 – 2037
State net operating loss carryforwards	$	108,133	2019 – 2036
Dutch net operating loss carryforwards	$	145,150	2020 – 2025

Schedule of Reconciliation of Unrecognized Tax Benefits

A reconciliation of the beginning and ending amount of unrecognized tax benefits for the years ended December 31, 2017 and 2016 is as follows:

	December 31,
	2017			2016
Balance at beginning of period	$	103,210		$	86,731
Additions based on tax positions related to the    current year		11,042			15,982
(Deletions) Additions for tax positions of prior years		(766	)	497
Balance at end of period	$	113,486		$	103,210