Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income Tax Contingency [Line Items]
Impairment	$ 5,017	$ 5,005
Deferred income taxes	(228,054)	(76,827)	$ (25,617)
Net operating loss carryforwards	49,787	44,942
Valuation allowance increase	5,300	$ 59,900
Unrecognized tax benefits that would affect the effective tax rate if recognized	103,200
Undistributed earnings of foreign subsidiaries	$ 3,900
Minimum
Income Tax Contingency [Line Items]
Income Tax Statute Of Limitations Period	3 years
Maximum
Income Tax Contingency [Line Items]
Income Tax Statute Of Limitations Period	5 years
Federal
Income Tax Contingency [Line Items]
Net operating loss carryforwards	$ 18,900
Research credit carry forward	$ 377,400
Federal | Minimum
Income Tax Contingency [Line Items]
Operating loss carry forward if not utilized, expiration date	2028
Research credit carryovers if not utilized, expiration date	2024
Federal | Maximum
Income Tax Contingency [Line Items]
Operating loss carry forward if not utilized, expiration date	2033
Research credit carryovers if not utilized, expiration date	2036
State
Income Tax Contingency [Line Items]
Net operating loss carryforwards	$ 174,700
Research credit carry forward	$ 71,700
State | Minimum
Income Tax Contingency [Line Items]
Operating loss carry forward if not utilized, expiration date	2017
Research credit carryovers if not utilized, expiration date	2019
State | Maximum
Income Tax Contingency [Line Items]
Operating loss carry forward if not utilized, expiration date	2036
Dutch | Foreign
Income Tax Contingency [Line Items]
Net operating loss carryforwards	$ 125,100
Dutch | Foreign | Minimum
Income Tax Contingency [Line Items]
Operating loss carry forward if not utilized, expiration date	2017
Dutch | Foreign | Maximum
Income Tax Contingency [Line Items]
Operating loss carry forward if not utilized, expiration date	2025
Dutch | Kyndrisa | IPR&D
Income Tax Contingency [Line Items]
Impairment	$ 539,200
Deferred income taxes	$ 143,500