CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (630,210)	$ (171,799)	$ (133,969)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	96,912	47,187	45,871
Non-cash interest expense	29,930	28,493	27,225
Accretion of discount on investments	1,300	2,177	7,211
Stock-based compensation expense	134,641	111,525	86,410
Gain on sale of intangible asset	0	(369,498)	(67,500)
Gain on termination of leases	0	0	(10,092)
(Gain) loss on sale of equity investment	108	(3,022)	0
Impairment of assets	599,118	211,502	0
Deferred income taxes	(228,054)	(76,827)	(25,617)
Unrealized foreign exchange gain on forward contracts	(14,481)	(19,575)	(832)
Non-cash changes in the fair value of contingent acquisition consideration payable	(57,161)	(28,457)	11,567
Other	336	2,463	5,188
Changes in operating assets and liabilities:
Accounts receivable, net	(51,483)	(16,367)	(25,951)
Inventory	(64,512)	(50,989)	(22,339)
Other current assets	19,316	25,800	(2,211)
Other assets	(4,979)	(3,157)	(6,516)
Accounts payable and accrued liabilities	(53,205)	90,298	38,040
Other long-term liabilities	(5,413)	747	3,093
Net cash used in operating activities	(227,837)	(219,499)	(70,422)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(148,380)	(227,653)	(117,062)
Deposit on purchase of PKU rights	0	(371,756)	0
Maturities and sales of investments	367,569	424,713	808,313
Purchase of available-for-sale investments	(699,749)	(873,184)	(507,036)
Proceeds from sale of intangible asset	0	410,000	67,500
Business acquisitions, net of cash acquired	(2,789)	(538,392)	0
Investment in convertible promissory note	0	(3,326)	(52,288)
Other	(698)	0	(3,100)
Net cash provided by (used in) investing activities	(484,047)	(1,179,598)	196,327
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of stock options and the ESPP	74,227	63,045	79,904
Taxes paid related to net share settlement of equity awards	(59,469)	(22,989)	(7,768)
Proceeds from public offering of common stock, net	712,938	888,257	117,464
Payment of contingent acquisition consideration payable	0	0	(4,691)
Other	(588)	(2,590)	(711)
Net cash provided by financing activities	727,108	925,723	184,198
Effect of exchange rate changes on cash	(3,934)	(5,072)	(3,398)
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	11,290	(478,446)	306,705
Cash and cash equivalents:
Beginning of period	397,040	875,486	568,781
End of period	408,330	397,040	875,486
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for interest, net of interest capitalized into fixed assets	8,643	9,307	9,324
Cash paid for income taxes	95,857	16,084	34,986
Stock-based compensation capitalized into inventory	11,449	11,140	8,166
Depreciation capitalized into inventory	17,375	14,627	10,952
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Increase (decrease) in accounts payable and accrued liabilities related to fixed assets	20,158	(4,651)	16,766
Conversion of convertible debt, net	$ 8,928	$ 9,112	$ 21,324